What compounds affect the Metabolism of cofactors pathway?

83 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of cofactors pathway (Reactome ID: R-HSA-8978934). These compounds target 6 genes within this pathway.

What genes are in the Metabolism of cofactors pathway?

The Metabolism of cofactors pathway involves 6 genes. Key genes include: COQ8A, COQ8B, DHFR, HSP90AA1, IDH1, NOS3.

Metabolism of cofactors

REACTOME PATHWAY

Reactome: R-HSA-89789346 genes83 compounds

The Metabolism of cofactors pathway (Reactome ID: R-HSA-8978934) involves 6 genes and is affected by 83 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

COQ8A COQ8B DHFR HSP90AA1 IDH1 NOS3

Compounds Affecting Metabolism of cofactors

#	Compound	Targets Hit	Studies
1	2-Chloroadenosine 2-Chloroadenosine.	—	300
2	Methotrexate	—	289
3	Calcimycin	—	216
4	Ciclopirox	—	88
5	cycloheximide	—	300
6	Hexachlorophene	—	300
7	Miconazole	—	298
8	licochalcone	—	267
9	Mometasone Furoate	—	292
10	Dinitrochlorobenzene	—	300
11	Lovastatin	—	300
12	Methylene Blue	—	200
13	Sertraline	—	1,000
14	Simvastatin	—	1,000
15	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
16	6-Aminonicotinamide	—	300
17	Anisomycin	—	247
18	Astemizole Antihistamine drug now withdrawn from	—	280
19	Azacitidine	—	298
20	Azacitidine	—	300
21	Azathioprine	—	300
22	Carbazilquinone	—	48
23	Chlorhexidine	—	299
24	clofilium tosylate	—	4
25	colchine	—	2
26	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
27	Digitoxin	—	300
28	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
29	Digoxin	—	299
30	Ethinyl Estradiol	—	300
31	Fluspirilene	—	74
32	Imatinib Mesylate	—	300
33	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
34	Niclosamide	—	299
35	Nisoldipine	—	297
36	Nortriptyline	—	28
37	propionylpromazine hydrochloride	—	2
38	Quinestrol	—	194
39	Salmeterol Xinafoate	—	227
40	streptonigrin	—	299
41	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
42	Thioridazine	—	35
43	triflupromazine hydrochloride	—	12
44	Tubercidin	—	300
45	tyrphostin 9	—	2
46	vinblastine sulfate	—	81
47	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
48	triolimus [Supplementary Concept]	—	33
49	monorden	—	8
50	gedunin	—	54

About the Metabolism of cofactors Pathway

The Metabolism of cofactors pathway is catalogued in Reactome (ID: R-HSA-8978934) and involves 6 genes. In the BiohacksAI corpus, 83 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include COQ8A, COQ8B, DHFR, HSP90AA1, IDH1.