What genes are in the Signaling by Receptor Tyrosine Kinases pathway?

The Signaling by Receptor Tyrosine Kinases pathway involves 146 genes. Key genes include: ADAM10, ADAM17, AKT3, ALK, APH1A, APH1B, ATP6V1B2, AXL, BRAF, CDC37.

Signaling by Receptor Tyrosine Kinases

Q: What compounds affect the Signaling by Receptor Tyrosine Kinases pathway?

518 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by Receptor Tyrosine Kinases pathway (Reactome ID: R-HSA-9006934). These compounds target 146 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-9006934146 genes518 compounds

The Signaling by Receptor Tyrosine Kinases pathway (Reactome ID: R-HSA-9006934) involves 146 genes and is affected by 518 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 ADAM17 AKT3 ALK APH1A APH1B ATP6V1B2 AXL BRAF CDC37 CDC42 CDK5 CDK5R1 CHEK1 CMA1 CREB1 CSK CYBB DNMT1 DUSP3 EGFR EP300 ERBB2 ERBB3 ERBB4 ESR1 F3 FER FES FGF22+116 more

Compounds Affecting Signaling by Receptor Tyrosine Kinases

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	sp600125	—	117
4	Crizotinib	—	298
5	Axitinib	—	298
6	Quercetin	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	kenpaullone	—	8
9	chrysin	—	300
10	Afatinib	—	297
11	pictilisib	—	25
12	tyrphostin ag 1478	—	4
13	alsterpaullone	—	12
14	hydroxyfasudil [Supplementary Concept]	—	11
15	Bortezomib	—	300
16	egcg	—	300
17	celastrol	—	300
18	Kaempferols	—	300
19	cycloheximide	—	300
20	Triiodothyronine	—	300
21	Pregnanolone	—	298
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	Androsterone	—	300
24	Camptothecin	—	300
25	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
26	Vemurafenib	—	298
27	Resveratrol	—	298
28	Celecoxib	—	295
29	Masoprocol	—	300
30	Daunorubicin	—	298
31	Ursolic Acid	—	300
32	fisetin	—	78
33	gamma-Aminobutyric Acid	—	300
34	Bicuculline	—	300
35	Etomidate Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or	—	299
36	Dactinomycin	—	297
37	Hexachlorophene	—	300
38	Niclosamide	—	299
39	Clotrimazole	—	296
40	Emetine	—	298
41	Disulfiram	—	297
42	Sirolimus	—	300
43	torin 1	—	10
44	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
45	withaferin	—	300
46	Ciprofloxacin	—	1,000
47	Etiocholanolone	—	300
48	Ondansetron	—	299
49	Picrotoxin	—	300
50	Dihydroergocristine	—	187

About the Signaling by Receptor Tyrosine Kinases Pathway

The Signaling by Receptor Tyrosine Kinases pathway is catalogued in Reactome (ID: R-HSA-9006934) and involves 146 genes. In the BiohacksAI corpus, 518 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ADAM17, AKT3, ALK, APH1A.