What compounds affect the Biosynthesis of DHA-derived SPMs pathway?

596 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of DHA-derived SPMs pathway (Reactome ID: R-HSA-9018677). These compounds target 15 genes within this pathway.

What genes are in the Biosynthesis of DHA-derived SPMs pathway?

The Biosynthesis of DHA-derived SPMs pathway involves 15 genes. Key genes include: ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4.

Biosynthesis of DHA-derived SPMs

REACTOME PATHWAY

Reactome: R-HSA-901867715 genes596 compounds

The Biosynthesis of DHA-derived SPMs pathway (Reactome ID: R-HSA-9018677) involves 15 genes and is affected by 596 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX12 ALOX15 ALOX5 CYP1A1 CYP1A2 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 EPHX2 GPX4 HPGD LTA4H PTGS2

Compounds Affecting Biosynthesis of DHA-derived SPMs

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Kaempferols	—	300
5	cbd	—	298
6	cannabidiol	—	296
7	Hexachlorophene	—	300
8	Masoprocol	—	300
9	Celecoxib	—	295
10	Ethoxyquin Antioxidant; also	—	180
11	Ethidium	—	300
12	Disulfiram	—	297
13	Chlorhexidine	—	299
14	Piribedil	—	300
15	Clotrimazole	—	296
16	Sulindac	—	297
17	Phenelzine	—	297
18	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
19	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
20	amlexanox	—	96
21	ethopropazine hydrochloride	—	2
22	Iodoacetamide	—	300
23	Linoleic Acid	—	300
24	pd98059	—	7
25	Procarbazine	—	299
26	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
27	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
28	Pseudoephedrine	—	298
29	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
30	Hesperidin	—	300
31	fisetin	—	78
32	Methoxsalen	—	300
33	Amoxapine	—	259
34	Danazol	—	298
35	Tolazamide	—	169
36	Piperonyl Butoxide	—	300
37	Methylene Blue	—	200
38	Melphalan	—	300
39	Vitamin K 3	—	300
40	Miconazole	—	298
41	oxatomide [Supplementary Concept] structure;	—	128
42	Phenelzine	—	2
43	Reserpine	—	297
44	Melatonin	—	297
45	Flutamide	—	298
46	Fluvoxamine	—	297
47	Nisoldipine	—	297
48	Phenylthiourea Phenylthiourea is	—	300
49	Bufexamac	—	137
50	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300

About the Biosynthesis of DHA-derived SPMs Pathway

The Biosynthesis of DHA-derived SPMs pathway is catalogued in Reactome (ID: R-HSA-9018677) and involves 15 genes. In the BiohacksAI corpus, 596 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2.