What genes are in the Transcriptional regulation of granulopoiesis pathway?

The Transcriptional regulation of granulopoiesis pathway involves 12 genes. Key genes include: CBFB, CDK2, CDK4, CREB1, EP300, KLF5, KMT2A, MYC, RARA, RUNX1.

Transcriptional regulation of granulopoiesis

Q: What compounds affect the Transcriptional regulation of granulopoiesis pathway?

218 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional regulation of granulopoiesis pathway (Reactome ID: R-HSA-9616222). These compounds target 12 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-961622212 genes218 compounds

The Transcriptional regulation of granulopoiesis pathway (Reactome ID: R-HSA-9616222) involves 12 genes and is affected by 218 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CBFB CDK2 CDK4 CREB1 EP300 KLF5 KMT2A MYC RARA RUNX1 RXRA STAT3

Compounds Affecting Transcriptional regulation of granulopoiesis

#	Compound	Targets Hit	Studies
1	Ethidium	—	300
2	Disulfiram	—	297
3	Daunorubicin	—	298
4	Aurintricarboxylic Acid	—	184
5	Dactinomycin	—	297
6	Danazol	—	298
7	Genistein	—	300
8	Testosterone	—	299
9	Niclosamide	—	299
10	Progesterone	—	299
11	cycloheximide	—	300
12	Hexachlorophene	—	300
13	Azacitidine	—	298
14	Azacitidine	—	300
15	Celecoxib	—	295
16	Vitamin	—	295
17	Nisoldipine	—	297
18	Rotenone	—	300
19	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
20	Colchicine	—	300
21	Dasatinib	—	299
22	Emetine	—	298
23	Flutamide	—	298
24	Gemfibrozil	—	297
25	o-Phthalaldehyde	—	300
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	chrysin	—	300
28	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
29	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
30	Bortezomib	—	300
31	Calcitriol	—	300
32	Cladribine	—	297
33	Dihydrotestosterone	—	300
34	Ethinyl Estradiol	—	300
35	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
36	Piperazine	—	299
37	Podophyllotoxin	—	14
38	Retinaldehyde	—	300
39	Sulfanilamide	—	300
40	Quercetin	—	300
41	Dihydroxyphenylalanine	—	300
42	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
43	Fusaric Acid	—	300
44	Harmaline	—	300
45	Adapalene	—	296
46	Astemizole Antihistamine drug now withdrawn from	—	280
47	Dinitrochlorobenzene	—	300
48	Norethindrone	—	300
49	Oxymetholone	—	298
50	Promethazine	—	121

About the Transcriptional regulation of granulopoiesis Pathway

The Transcriptional regulation of granulopoiesis pathway is catalogued in Reactome (ID: R-HSA-9616222) and involves 12 genes. In the BiohacksAI corpus, 218 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CBFB, CDK2, CDK4, CREB1, EP300.