What compounds affect the Selective autophagy pathway?

170 compounds in the BiohacksAI corpus have documented interactions with genes in the Selective autophagy pathway (Reactome ID: R-HSA-9663891). These compounds target 41 genes within this pathway.

What genes are in the Selective autophagy pathway?

The Selective autophagy pathway involves 41 genes. Key genes include: ATM, CFTR, CSNK2A1, CSNK2A2, CSNK2B, EPAS1, HDAC6, HSP90AA1, HSPA8, MAP1LC3A.

Selective autophagy

REACTOME PATHWAY

Reactome: R-HSA-966389141 genes170 compounds

The Selective autophagy pathway (Reactome ID: R-HSA-9663891) involves 41 genes and is affected by 170 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM CFTR CSNK2A1 CSNK2A2 CSNK2B EPAS1 HDAC6 HSP90AA1 HSPA8 MAP1LC3A MAP1LC3B PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRKN SRC TBK1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A+11 more

Compounds Affecting Selective autophagy

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Vorinostat	—	299
4	Podophyllotoxin	—	14
5	vinblastine sulfate	—	81
6	Vincristine	—	299
7	Noscapine	—	300
8	Demecolcine	—	246
9	Maytansine	—	300
10	Niclosamide	—	299
11	Quercetin	—	300
12	Ursolic Acid	—	300
13	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
14	Adenosine Monophosphate Adenine nucleotide containing	—	300
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
17	Proguanil	—	299
18	Berberine	—	300
19	Antimycin	—	300
20	Oleanolic Acid	—	300
21	Rotenone	—	300
22	Metformin	—	1,000
23	Hexachlorophene	—	300
24	Kaempferols	—	300
25	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
26	kenpaullone	—	8
27	chrysin	—	300
28	fisetin	—	78
29	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
30	Genistein	—	300
31	cycloheximide	—	300
32	alsterpaullone	—	12
33	Axitinib	—	298
34	piceatannol	—	300
35	Novobiocin	—	300
36	Vanillic Acid	—	300
37	ly294002	—	11
38	Crizotinib	—	298
39	Anisomycin	—	247
40	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
41	Medroxyprogesterone Acetate	—	299
42	Mestranol	—	300
43	Methylene Blue	—	200
44	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
45	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
46	Digoxin	—	299
47	Disulfiram	—	297
48	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
49	Oxyphenbutazone	—	300
50	scriptaid	—	53

About the Selective autophagy Pathway

The Selective autophagy pathway is catalogued in Reactome (ID: R-HSA-9663891) and involves 41 genes. In the BiohacksAI corpus, 170 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, CFTR, CSNK2A1, CSNK2A2, CSNK2B.