What compounds affect the FCGR3A-mediated IL10 synthesis pathway?

242 compounds in the BiohacksAI corpus have documented interactions with genes in the FCGR3A-mediated IL10 synthesis pathway (Reactome ID: R-HSA-9664323). These compounds target 13 genes within this pathway.

What genes are in the FCGR3A-mediated IL10 synthesis pathway?

The FCGR3A-mediated IL10 synthesis pathway involves 13 genes. Key genes include: ADCY9, CREB1, FGR, FYN, HCK, LYN, PRKACA, PRKACB, PRKACG, PRKX.

FCGR3A-mediated IL10 synthesis

REACTOME PATHWAY

Reactome: R-HSA-966432313 genes242 compounds

The FCGR3A-mediated IL10 synthesis pathway (Reactome ID: R-HSA-9664323) involves 13 genes and is affected by 242 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 CREB1 FGR FYN HCK LYN PRKACA PRKACB PRKACG PRKX SRC SYK YES1

Compounds Affecting FCGR3A-mediated IL10 synthesis

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	tyrphostin ag 1478	—	4
3	Sorafenib	—	300
4	Crizotinib	—	298
5	Quercetin	—	300
6	kenpaullone	—	8
7	hydroxyfasudil [Supplementary Concept]	—	11
8	Disulfiram	—	297
9	Axitinib	—	298
10	Afatinib	—	297
11	Cladribine	—	297
12	alsterpaullone	—	12
13	sp600125	—	117
14	Clofarabine	—	298
15	cycloheximide	—	300
16	Emetine	—	298
17	Niclosamide	—	299
18	alpelisib	—	227
19	Bortezomib	—	300
20	Nocodazole Nocodazole is	—	215
21	Danazol	—	298
22	Daunorubicin	—	298
23	Ethinyl Estradiol	—	300
24	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
25	monorden	—	8
26	Nisoldipine	—	297
27	pictilisib	—	25
28	Tilorone	—	300
29	trequinsin hydrochloride	—	1
30	Vemurafenib	—	298
31	chrysin	—	300
32	Kaempferols	—	300
33	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
34	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
35	Azacitidine	—	298
36	Azacitidine	—	300
37	Ciclopirox	—	88
38	Edaravone	—	298
39	Ethidium	—	300
40	Adenosine Monophosphate Adenine nucleotide containing	—	300
41	Genistein	—	300
42	Ouabain	—	300
43	Atorvastatin	—	1,000
44	Simvastatin	—	1,000
45	Methotrexate	—	289
46	Chlorhexidine	—	299
47	Colchicine	—	300
48	deguelin [Supplementary Concept]	—	151
49	Digoxin	—	299
50	Ezetimibe	—	296

About the FCGR3A-mediated IL10 synthesis Pathway

The FCGR3A-mediated IL10 synthesis pathway is catalogued in Reactome (ID: R-HSA-9664323) and involves 13 genes. In the BiohacksAI corpus, 242 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, CREB1, FGR, FYN, HCK.