What compounds affect the SARS-CoV Infections pathway?

530 compounds in the BiohacksAI corpus have documented interactions with genes in the SARS-CoV Infections pathway (Reactome ID: R-HSA-9679506). These compounds target 91 genes within this pathway.

What genes are in the SARS-CoV Infections pathway?

The SARS-CoV Infections pathway involves 91 genes. Key genes include: AKT3, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, BCL2L1, BRD4.

SARS-CoV Infections

REACTOME PATHWAY

Reactome: R-HSA-967950691 genes530 compounds

The SARS-CoV Infections pathway (Reactome ID: R-HSA-9679506) involves 91 genes and is affected by 530 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 BCL2L1 BRD4 BTK CASP1 CHUK CHURC1-FNTB CREBBP CSNK1A1 CTSL CYSLTR1 EP300 FKBP1A FKBP4 FNTA FNTB FURIN FXYD2 GALNT1 GANAB GRB2 GSK3A GSK3B+61 more

Compounds Affecting SARS-CoV Infections

#	Compound	Targets Hit	Studies
1	Digitoxin	—	300
2	Digoxin	—	299
3	Ouabain	—	300
4	Crizotinib	—	298
5	Quercetin	—	300
6	Disulfiram	—	297
7	Hexachlorophene	—	300
8	Bortezomib	—	300
9	sp600125	—	117
10	cycloheximide	—	300
11	Sorafenib	—	300
12	Daunorubicin	—	298
13	Camptothecin	—	300
14	kenpaullone	—	8
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	Axitinib	—	298
17	Kaempferols	—	300
18	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
19	Lovastatin	—	300
20	alsterpaullone	—	12
21	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
22	chrysin	—	300
23	Podophyllotoxin	—	14
24	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
25	Astemizole Antihistamine drug now withdrawn from	—	280
26	Idarubicin	—	299
27	egcg	—	300
28	Azacitidine	—	298
29	Azacitidine	—	300
30	Methylene Blue	—	200
31	vinblastine sulfate	—	81
32	Dactinomycin	—	297
33	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
34	Masoprocol	—	300
35	Chlorhexidine	—	299
36	Dasatinib	—	299
37	celastrol	—	300
38	triolimus [Supplementary Concept]	—	33
39	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
40	Calcimycin	—	216
41	Resveratrol	—	298
42	Colchicine	—	300
43	Genistein	—	300
44	Niclosamide	—	299
45	Ethidium	—	300
46	Nocodazole Nocodazole is	—	215
47	Oxyphenbutazone	—	300
48	Celecoxib	—	295
49	Nisoldipine	—	297
50	Deslanoside Deacetyllanatoside C.	—	89

About the SARS-CoV Infections Pathway

The SARS-CoV Infections pathway is catalogued in Reactome (ID: R-HSA-9679506) and involves 91 genes. In the BiohacksAI corpus, 530 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, ATP1A1, ATP1A2, ATP1A3, ATP1A4.