Class I MHC mediated antigen processing & presentation

Q: What compounds affect the Class I MHC mediated antigen processing & presentation pathway?

88 compounds in the BiohacksAI corpus have documented interactions with genes in the Class I MHC mediated antigen processing & presentation pathway (Reactome ID: R-HSA-983169). These compounds target 58 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98316958 genes88 compounds

The Class I MHC mediated antigen processing & presentation pathway (Reactome ID: R-HSA-983169) involves 58 genes and is affected by 88 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 BTK CHUK CTSL CUL1 CYBB HLA-A HLA-B HMGB1 HSPA5 IKBKB ITGAV NCF1 NPEPPS PDIA3 PIK3C3 PRKN PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5+28 more

Compounds Affecting Class I MHC mediated antigen processing & presentation

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Crizotinib	—	298
4	Genistein	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	candesartan cilexetil [Supplementary Concept]	—	300
7	celastrol	—	300
8	Disulfiram	—	297
9	kenpaullone	—	8
10	Sertraline	—	1,000
11	Nitrendipine	—	299
12	chrysin	—	300
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
15	Astemizole Antihistamine drug now withdrawn from	—	280
16	Hexachlorophene	—	300
17	chicoric acid	—	117
18	sp600125	—	117
19	ninhydrin	—	300
20	Camptothecin	—	300
21	Ouabain	—	300
22	withaferin	—	300
23	Idarubicin	—	299
24	Azacitidine	—	298
25	Azacitidine	—	300
26	Calcimycin	—	216
27	cycloheximide	—	300
28	Dactinomycin	—	297
29	Daunorubicin	—	298
30	Emetine	—	298
31	Epirubicin	—	300
32	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
33	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
34	Proscillaridin	—	219
35	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
36	Tripterygium	—	300
37	cbd	—	298
38	cannabidiol	—	296
39	Deslanoside Deacetyllanatoside C.	—	89
40	Digitoxin	—	300
41	Digoxin	—	299
42	Feprazone	—	63
43	Leflunomide	—	297
44	Phenylbutazone	—	300
45	triolimus [Supplementary Concept]	—	33
46	Thapsigargin	—	300
47	4-Hydroxybenzoate-3-Monooxygenase	—	300
48	egcg	—	300
49	Quercetin	—	300
50	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300

About the Class I MHC mediated antigen processing & presentation Pathway

The Class I MHC mediated antigen processing & presentation pathway is catalogued in Reactome (ID: R-HSA-983169) and involves 58 genes. In the BiohacksAI corpus, 88 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, BTK, CHUK, CTSL, CUL1.