What compounds affect the Signaling by TGFBR3 pathway?

203 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by TGFBR3 pathway (Reactome ID: R-HSA-9839373). These compounds target 16 genes within this pathway.

What genes are in the Signaling by TGFBR3 pathway?

The Signaling by TGFBR3 pathway involves 16 genes. Key genes include: ACVR2A, AGO2, APH1A, APH1B, ARRB1, EP300, MMP14, NCSTN, PSEN1, PSEN2.

Signaling by TGFBR3

REACTOME PATHWAY

Reactome: R-HSA-983937316 genes203 compounds

The Signaling by TGFBR3 pathway (Reactome ID: R-HSA-9839373) involves 16 genes and is affected by 203 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ACVR2A AGO2 APH1A APH1B ARRB1 EP300 MMP14 NCSTN PSEN1 PSEN2 PSENEN RARA RXRA SMAD3 TGFBR1 TGFBR2

Compounds Affecting Signaling by TGFBR3

#	Compound	Targets Hit	Studies
1	Dihydroergocristine	—	187
2	Dasatinib	—	299
3	Astemizole Antihistamine drug now withdrawn from	—	280
4	Dactinomycin	—	297
5	Ethidium	—	300
6	Rotenone	—	300
7	Flutamide	—	298
8	Disulfiram	—	297
9	Progesterone	—	299
10	cycloheximide	—	300
11	Hexachlorophene	—	300
12	Azacitidine	—	298
13	Azacitidine	—	300
14	Celecoxib	—	295
15	Danazol	—	298
16	Dinitrochlorobenzene	—	300
17	Promethazine	—	121
18	Genistein	—	300
19	Vitamin	—	295
20	Nisoldipine	—	297
21	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
22	Methylene Blue	—	200
23	Resveratrol	—	298
24	Testosterone	—	299
25	Colchicine	—	300
26	Daunorubicin	—	298
27	Emetine	—	298
28	Fluspirilene	—	74
29	Gemfibrozil	—	297
30	Idazoxan	—	300
31	Leflunomide	—	297
32	Lynestrenol	—	299
33	Niclosamide	—	299
34	o-Phthalaldehyde	—	300
35	triflupromazine hydrochloride	—	12
36	Vincristine	—	299
37	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
38	chrysin	—	300
39	Fluoxetine	—	1,000
40	Kaempferols	—	300
41	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
42	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
43	Bortezomib	—	300
44	Calcitriol	—	300
45	Cladribine	—	297
46	Dihydrotestosterone	—	300
47	Ethinyl Estradiol	—	300
48	Loratadine	—	296
49	Nicardipine	—	94
50	Perphenazine	—	297

About the Signaling by TGFBR3 Pathway

The Signaling by TGFBR3 pathway is catalogued in Reactome (ID: R-HSA-9839373) and involves 16 genes. In the BiohacksAI corpus, 203 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ACVR2A, AGO2, APH1A, APH1B, ARRB1.