What compounds affect the Dengue Virus Infection pathway?

117 compounds in the BiohacksAI corpus have documented interactions with genes in the Dengue Virus Infection pathway (Reactome ID: R-HSA-9839923). These compounds target 43 genes within this pathway.

What genes are in the Dengue Virus Infection pathway?

The Dengue Virus Infection pathway involves 43 genes. Key genes include: AXL, CAMK2B, CAMK2D, CGAS, EIF4A1, EIF4G1, ELAVL1, FASN, FURIN, HNRNPA1.

Dengue Virus Infection

REACTOME PATHWAY

Reactome: R-HSA-983992343 genes117 compounds

The Dengue Virus Infection pathway (Reactome ID: R-HSA-9839923) involves 43 genes and is affected by 117 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AXL CAMK2B CAMK2D CGAS EIF4A1 EIF4G1 ELAVL1 FASN FURIN HNRNPA1 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA5 HSPA8 IKBKE KPNB1 LYN MAP1LC3B MAPKAP1 MERTK MLST8 MTOR NEK2 NFKBIA P4HB PABPC1 PDIA3 PIK3C3+13 more

Compounds Affecting Dengue Virus Infection

#	Compound	Targets Hit	Studies
1	Hexachlorophene	—	300
2	Quercetin	—	300
3	torin 1	—	10
4	sp600125	—	117
5	egcg	—	300
6	Crizotinib	—	298
7	Ku 0063794 [Supplementary Concept]	—	7
8	Sorafenib	—	300
9	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
10	Idarubicin	—	299
11	Wortmannin	—	300
12	Sirolimus	—	300
13	Oxytetracycline	—	300
14	Ergosterol	—	300
15	triolimus [Supplementary Concept]	—	33
16	gedunin	—	54
17	Novobiocin	—	300
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	Disulfiram	—	297
20	pictilisib	—	25
21	Everolimus	—	297
22	Dasatinib	—	299
23	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
24	monorden	—	8
25	celastrol	—	300
26	caffeic acid	—	300
27	Masoprocol	—	300
28	Tetracycline	—	300
29	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
30	ag490	—	14
31	Calcimycin	—	216
32	Clotrimazole	—	296
33	cycloheximide	—	300
34	piceatannol	—	300
35	Nitroprusside	—	299
36	ly294002	—	11
37	alpelisib	—	227
38	Camptothecin	—	300
39	Dequalinium	—	136
40	amlexanox	—	96
41	Cefixime	—	300
42	Azauridine	—	300
43	alsterpaullone	—	12
44	Axitinib	—	298
45	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
46	Adenosine Triphosphate	—	300
47	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
48	2-Chloroadenosine 2-Chloroadenosine.	—	300
49	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
50	Calcitriol	—	300

About the Dengue Virus Infection Pathway

The Dengue Virus Infection pathway is catalogued in Reactome (ID: R-HSA-9839923) and involves 43 genes. In the BiohacksAI corpus, 117 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AXL, CAMK2B, CAMK2D, CGAS, EIF4A1.