What compounds affect the Adipogenesis pathway?

191 compounds in the BiohacksAI corpus have documented interactions with genes in the Adipogenesis pathway (Reactome ID: R-HSA-9843745). These compounds target 26 genes within this pathway.

What genes are in the Adipogenesis pathway?

The Adipogenesis pathway involves 26 genes. Key genes include: CARM1, CCNC, CDK19, CDK4, CDK8, CREBBP, EP300, FABP4, HDAC1, HDAC2.

Adipogenesis

REACTOME PATHWAY

Reactome: R-HSA-984374526 genes191 compounds

The Adipogenesis pathway (Reactome ID: R-HSA-9843745) involves 26 genes and is affected by 191 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CARM1 CCNC CDK19 CDK4 CDK8 CREBBP EP300 FABP4 HDAC1 HDAC2 HDAC3 KLF5 NCOA1 NCOA3 NCOR1 NCOR2 NFKB1 NR2F2 PLIN1 PPARA PPARG RELA RXRA SLC2A4 SREBF1 SREBF2

Compounds Affecting Adipogenesis

#	Compound	Targets Hit	Studies
1	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
2	Bortezomib	—	300
3	Ursolic Acid	—	300
4	Vorinostat	—	299
5	Arachidonic Acid	—	245
6	Quercetin	—	300
7	cycloheximide	—	300
8	Daunorubicin	—	298
9	Trifluridine	—	295
10	alsterpaullone	—	12
11	Digoxin	—	299
12	scriptaid	—	53
13	Camptothecin	—	300
14	Methylene Blue	—	200
15	urolithin b	—	49
16	Linoleic Acid	—	300
17	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
18	Kaempferols	—	300
19	Resveratrol	—	298
20	Disulfiram	—	297
21	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
22	Oleic Acid	—	112
23	Rutin	—	300
24	Methotrexate	—	289
25	Hexachlorophene	—	300
26	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
27	Podophyllotoxin	—	14
28	Anisomycin	—	247
29	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
30	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
31	Tubercidin	—	300
32	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
33	Valproic Acid	—	296
34	pictilisib	—	25
35	Butyric Acid	—	300
36	Celecoxib	—	295
37	Sorafenib	—	300
38	Pioglitazone	—	297
39	Troglitazone	—	299
40	Thyroxine	—	994
41	Thyroxine	—	300
42	Genistein	—	300
43	Rotenone	—	300
44	alpha-Linolenic Acid	—	300
45	Bezafibrate	—	300
46	Mepentol [Supplementary Concept]	—	184
47	Ethidium	—	300
48	Fenofibrate	—	297
49	Niflumic Acid	—	300
50	Oxaprozin	—	181

About the Adipogenesis Pathway

The Adipogenesis pathway is catalogued in Reactome (ID: R-HSA-9843745) and involves 26 genes. In the BiohacksAI corpus, 191 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CARM1, CCNC, CDK19, CDK4, CDK8.