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BiohacksAI/Compounds/Amethopterin/Similar

Compounds Similar to Amethopterin

10 compounds with shared biological targets · BiohacksAI corpus v20260307-01

The compounds below share molecular targets and biological mechanisms with Amethopterin, including interactions with DHFR, ESRRA, ATXN2. Similarity is calculated using target-weighted Jaccard scoring across the BiohacksAI BindingDB corpus. Higher shared target counts indicate stronger mechanistic overlap.

View Amethopterin profile →OXIDATIVE STRESS pathwayGLUCOSE METABOLISM pathway
Similar Compounds — Ranked by Target Overlap
1
Pemetrexed
14
shared
299
studies
27%
overlap
2
Cytarabine
21
shared
297
studies
26%
overlap
3
Trifluridine
19
shared
295
studies
24%
overlap
4
Melphalan
23
shared
300
studies
23%
overlap
5
Azacitidine
21
shared
298
studies
21%
overlap
6
Azacytidine
21
shared
300
studies
21%
overlap
7
methotrexate
9
shared
21%
overlap
8
Cycloheximide
26
shared
300
studies
21%
overlap
9
vinblastine
26
shared
81
studies
20%
overlap
10
Azathioprine
19
shared
300
studies
19%
overlap
Shared Biological Targets
DHFRSLC46A1TYMSGARTFOLATEATXN2CYTOCHROMEMDM2

Click a target to see all compounds with interactions at that molecular target.

Similarity between compounds is computed using IDF-weighted Jaccard scoring across shared molecular targets in the BiohacksAI BindingDB corpus. Compounds with higher overlap scores share more targets, weighted by how specific those targets are across the entire corpus.

Explore related resources: Amethopterin full profile · Browse all compounds · Biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.