What compounds affect the Metabolism pathway?

999 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism pathway (Reactome ID: R-HSA-1430728). These compounds target 377 genes within this pathway.

What genes are in the Metabolism pathway?

The Metabolism pathway involves 377 genes. Key genes include: AADAC, AASDHPPT, ABCB11, ABCC1, ABCC2, ABCC3, ABCC5, ABCC8, ABCG2, ACAD11.

Metabolism

REACTOME PATHWAY

Reactome: R-HSA-1430728377 genes999 compounds

The Metabolism pathway (Reactome ID: R-HSA-1430728) involves 377 genes and is affected by 999 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AADAC AASDHPPT ABCB11 ABCC1 ABCC2 ABCC3 ABCC5 ABCC8 ABCG2 ACAD11 ACHE ADA ADCY9 ADK ADRA2A ADRA2C ADRM1 AGL AHCY AHR AKR1B10 AKR1C1 AKR1C2 AKR1C3 AKR1C4 ALB ALDH1A1 ALDH2 ALOX12 ALOX15+347 more

Compounds Affecting Metabolism

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Bortezomib	—	300
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Disulfiram	—	297
6	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
7	chrysin	—	300
8	Reserpine	—	297
9	Chlorhexidine	—	299
10	Resveratrol	—	298
11	Kaempferols	—	300
12	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
13	Genistein	—	300
14	Hexachlorophene	—	300
15	Celecoxib	—	295
16	Aurintricarboxylic Acid	—	184
17	Clotrimazole	—	296
18	Vitamin K 3	—	300
19	Ethidium	—	300
20	Methylene Blue	—	200
21	egcg	—	300
22	Astemizole Antihistamine drug now withdrawn from	—	280
23	Methotrexate	—	289
24	Daunorubicin	—	298
25	Thyroxine	—	994
26	Thyroxine	—	300
27	piceatannol	—	300
28	Rotenone	—	300
29	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
30	Miconazole	—	298
31	Troglitazone	—	299
32	Iodoacetamide	—	300
33	Masoprocol	—	300
34	Triiodothyronine	—	300
35	Niclosamide	—	299
36	Crizotinib	—	298
37	caffeic acid	—	300
38	pictilisib	—	25
39	Ritonavir	—	298
40	Linoleic Acid	—	300
41	Ethinyl Estradiol	—	300
42	Nisoldipine	—	297
43	Pueraria	—	300
44	Gemfibrozil	—	297
45	Sulfanilamide	—	300
46	Kaempferols	—	300
47	Indapamide	—	299
48	Arachidonic Acid	—	245
49	Progesterone	—	299
50	Hesperidin	—	300

About the Metabolism Pathway

The Metabolism pathway is catalogued in Reactome (ID: R-HSA-1430728) and involves 377 genes. In the BiohacksAI corpus, 999 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AADAC, AASDHPPT, ABCB11, ABCC1, ABCC2.