What compounds affect the Organelle biogenesis and maintenance pathway?

362 compounds in the BiohacksAI corpus have documented interactions with genes in the Organelle biogenesis and maintenance pathway (Reactome ID: R-HSA-1852241). These compounds target 53 genes within this pathway.

What genes are in the Organelle biogenesis and maintenance pathway?

The Organelle biogenesis and maintenance pathway involves 53 genes. Key genes include: CARM1, CCT2, CDK1, CREB1, CREBBP, CSNK1D, CSNK1E, ESRRA, HDAC3, HDAC6.

Organelle biogenesis and maintenance

REACTOME PATHWAY

Reactome: R-HSA-185224153 genes362 compounds

The Organelle biogenesis and maintenance pathway (Reactome ID: R-HSA-1852241) involves 53 genes and is affected by 362 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CARM1 CCT2 CDK1 CREB1 CREBBP CSNK1D CSNK1E ESRRA HDAC3 HDAC6 HSP90AA1 MAPK11 MAPK12 MAPK14 MCHR1 NCOA1 NCOR1 NEK2 NR1D1 PLK1 PLK4 POLRMT PPARA PRKAA2 PRKAB1 PRKAB2 PRKACA PRKAG1 PRKAG2 PRKAG3+23 more

Compounds Affecting Organelle biogenesis and maintenance

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Vorinostat	—	299
4	Podophyllotoxin	—	14
5	vinblastine sulfate	—	81
6	Vincristine	—	299
7	Noscapine	—	300
8	Demecolcine	—	246
9	Maytansine	—	300
10	Quercetin	—	300
11	Rotenone	—	300
12	Ursolic Acid	—	300
13	Niclosamide	—	299
14	Adenosine Monophosphate Adenine nucleotide containing	—	300
15	sp600125	—	117
16	Berberine	—	300
17	Dasatinib	—	299
18	Proguanil	—	299
19	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
20	Antimycin	—	300
21	Oleanolic Acid	—	300
22	Metformin	—	1,000
23	pictilisib	—	25
24	Sorafenib	—	300
25	Genistein	—	300
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	Disulfiram	—	297
28	Hexachlorophene	—	300
29	cycloheximide	—	300
30	chrysin	—	300
31	Celecoxib	—	295
32	Camptothecin	—	300
33	Daunorubicin	—	298
34	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
35	Anisomycin	—	247
36	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
37	Azacitidine	—	298
38	Azacitidine	—	300
39	Clotrimazole	—	296
40	Methylene Blue	—	200
41	Ethidium	—	300
42	Axitinib	—	298
43	Bortezomib	—	300
44	Fenofibrate	—	297
45	Nisoldipine	—	297
46	Testosterone	—	299
47	kenpaullone	—	8
48	piceatannol	—	300
49	Kaempferols	—	300
50	Dactinomycin	—	297

About the Organelle biogenesis and maintenance Pathway

The Organelle biogenesis and maintenance pathway is catalogued in Reactome (ID: R-HSA-1852241) and involves 53 genes. In the BiohacksAI corpus, 362 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CARM1, CCT2, CDK1, CREB1, CREBBP.