What compounds affect the Metabolism of vitamins and cofactors pathway?

187 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of vitamins and cofactors pathway (Reactome ID: R-HSA-196854). These compounds target 36 genes within this pathway.

What genes are in the Metabolism of vitamins and cofactors pathway?

The Metabolism of vitamins and cofactors pathway involves 36 genes. Key genes include: AASDHPPT, ABCC1, AKR1B10, AKR1C1, AKR1C3, AKR1C4, AOX1, CD38, COQ8A, COQ8B.

Metabolism of vitamins and cofactors

REACTOME PATHWAY

Reactome: R-HSA-19685436 genes187 compounds

The Metabolism of vitamins and cofactors pathway (Reactome ID: R-HSA-196854) involves 36 genes and is affected by 187 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AASDHPPT ABCC1 AKR1B10 AKR1C1 AKR1C3 AKR1C4 AOX1 CD38 COQ8A COQ8B CTRB1 DHFR ENPP2 FASN FPGS GSTO1 HSP90AA1 IDH1 NADK NAPRT NNMT NOS3 PDXK PNLIP PRSS1 PRSS3 RBP4 SHMT2 SLC19A1 SLC23A1+6 more

Compounds Affecting Metabolism of vitamins and cofactors

#	Compound	Targets Hit	Studies
1	Methotrexate	—	289
2	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
3	Quercetin	—	300
4	egcg	—	300
5	Calcimycin	—	216
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Pemetrexed	—	299
9	cycloheximide	—	300
10	Hexachlorophene	—	300
11	piceatannol	—	300
12	Masoprocol	—	300
13	Kaempferols	—	300
14	Genistein	—	300
15	Resveratrol	—	298
16	Leucovorin	—	297
17	Bortezomib	—	300
18	Methylene Blue	—	200
19	2-Chloroadenosine 2-Chloroadenosine.	—	300
20	6-Aminonicotinamide	—	300
21	Anisomycin	—	247
22	Chlorhexidine	—	299
23	Ciclopirox	—	88
24	Ethinyl Estradiol	—	300
25	Miconazole	—	298
26	propionylpromazine hydrochloride	—	2
27	tyrphostin 9	—	2
28	Crizotinib	—	298
29	Dasatinib	—	299
30	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
31	Thyroxine	—	994
32	Disulfiram	—	297
33	Thyroxine	—	300
34	Triiodothyronine	—	300
35	gedunin	—	54
36	caffeic acid	—	300
37	Tetracycline	—	300
38	Kaempferols	—	300
39	Indomethacin	—	297
40	Vitamin	—	295
41	Vitamin K 3	—	300
42	Catechin	—	300
43	Glucose	—	294
44	Medroxyprogesterone Acetate	—	299
45	Sulfaguanidine	—	255
46	licochalcone	—	267
47	Mometasone Furoate	—	292
48	Dinitrochlorobenzene	—	300
49	Lovastatin	—	300
50	Sertraline	—	1,000

About the Metabolism of vitamins and cofactors Pathway

The Metabolism of vitamins and cofactors pathway is catalogued in Reactome (ID: R-HSA-196854) and involves 36 genes. In the BiohacksAI corpus, 187 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AASDHPPT, ABCC1, AKR1B10, AKR1C1, AKR1C3.