What compounds affect the Post NMDA receptor activation events pathway?

118 compounds in the BiohacksAI corpus have documented interactions with genes in the Post NMDA receptor activation events pathway (Reactome ID: R-HSA-438064). These compounds target 49 genes within this pathway.

What genes are in the Post NMDA receptor activation events pathway?

The Post NMDA receptor activation events pathway involves 49 genes. Key genes include: CAMK1, CAMK2B, CAMK2D, CAMKK1, CAMKK2, CREB1, ERBB4, GRIA1, GRIA2, GRIN1.

Post NMDA receptor activation events

REACTOME PATHWAY

Reactome: R-HSA-43806449 genes118 compounds

The Post NMDA receptor activation events pathway (Reactome ID: R-HSA-438064) involves 49 genes and is affected by 118 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CAMK1 CAMK2B CAMK2D CAMKK1 CAMKK2 CREB1 ERBB4 GRIA1 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2C MAPK1 MAPK3 PDPK1 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKACG PRKAG1 PRKAG2 PRKAG3 PRKX RPS6KA1 RPS6KA2 RPS6KA3+19 more

Compounds Affecting Post NMDA receptor activation events

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Vincristine	—	299
4	Noscapine	—	300
5	Podophyllotoxin	—	14
6	Demecolcine	—	246
7	Maytansine	—	300
8	vinblastine sulfate	—	81
9	Vorinostat	—	299
10	Adenosine Monophosphate Adenine nucleotide containing	—	300
11	sp600125	—	117
12	Niclosamide	—	299
13	Proguanil	—	299
14	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
15	Berberine	—	300
16	Ursolic Acid	—	300
17	Antimycin	—	300
18	Oleanolic Acid	—	300
19	Rotenone	—	300
20	Metformin	—	1,000
21	Sorafenib	—	300
22	Glutamic Acid	—	297
23	Glutamic Acid	—	300
24	hydroxyfasudil [Supplementary Concept]	—	11
25	Ethidium	—	300
26	alsterpaullone	—	12
27	Quercetin	—	300
28	kenpaullone	—	8
29	fisetin	—	78
30	Glycine	—	300
31	pentamidine	—	299
32	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
33	Dextrorphan Dextro form of levorphanol. It acts as	—	300
34	Levorphanol	—	297
35	cycloserine	—	298
36	Aspartic Acid	—	300
37	D-Aspartic Acid	—	29
38	Dextrothyroxine	—	134
39	Dizocilpine Maleate	—	300
40	Ibotenic Acid	—	300
41	Spermine	—	300
42	Dasatinib	—	299
43	tyrphostin ag 1478	—	4
44	eliprodil	—	33
45	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
46	Afatinib	—	297
47	Crizotinib	—	298
48	pictilisib	—	25
49	trequinsin hydrochloride	—	1
50	plumbagin [Supplementary Concept]	—	300

About the Post NMDA receptor activation events Pathway

The Post NMDA receptor activation events pathway is catalogued in Reactome (ID: R-HSA-438064) and involves 49 genes. In the BiohacksAI corpus, 118 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK1, CAMK2B, CAMK2D, CAMKK1, CAMKK2.