Activation of NMDA receptors and postsynaptic events

Q: What compounds affect the Activation of NMDA receptors and postsynaptic events pathway?

118 compounds in the BiohacksAI corpus have documented interactions with genes in the Activation of NMDA receptors and postsynaptic events pathway (Reactome ID: R-HSA-442755). These compounds target 52 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-44275552 genes118 compounds

The Activation of NMDA receptors and postsynaptic events pathway (Reactome ID: R-HSA-442755) involves 52 genes and is affected by 118 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CAMK1 CAMK2B CAMK2D CAMKK1 CAMKK2 CASK CREB1 ERBB4 GRIA1 GRIA2 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C MAPK1 MAPK3 PDPK1 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKACG PRKAG1 PRKAG2 PRKAG3 PRKX+22 more

Compounds Affecting Activation of NMDA receptors and postsynaptic events

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Vincristine	—	299
4	Noscapine	—	300
5	Podophyllotoxin	—	14
6	Demecolcine	—	246
7	Maytansine	—	300
8	vinblastine sulfate	—	81
9	Vorinostat	—	299
10	Adenosine Monophosphate Adenine nucleotide containing	—	300
11	sp600125	—	117
12	Glutamic Acid	—	297
13	Glutamic Acid	—	300
14	Niclosamide	—	299
15	Proguanil	—	299
16	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
17	Berberine	—	300
18	Ursolic Acid	—	300
19	Antimycin	—	300
20	Oleanolic Acid	—	300
21	Rotenone	—	300
22	Metformin	—	1,000
23	Sorafenib	—	300
24	hydroxyfasudil [Supplementary Concept]	—	11
25	Ethidium	—	300
26	alsterpaullone	—	12
27	Quercetin	—	300
28	kenpaullone	—	8
29	fisetin	—	78
30	Glycine	—	300
31	pentamidine	—	299
32	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
33	Dextrorphan Dextro form of levorphanol. It acts as	—	300
34	Levorphanol	—	297
35	cycloserine	—	298
36	Aspartic Acid	—	300
37	D-Aspartic Acid	—	29
38	Dextrothyroxine	—	134
39	Dizocilpine Maleate	—	300
40	Ibotenic Acid	—	300
41	Spermine	—	300
42	Crizotinib	—	298
43	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	—	300
44	aniracetam	—	110
45	Piracetam	—	300
46	Dasatinib	—	299
47	tyrphostin ag 1478	—	4
48	eliprodil	—	33
49	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
50	Afatinib	—	297

About the Activation of NMDA receptors and postsynaptic events Pathway

The Activation of NMDA receptors and postsynaptic events pathway is catalogued in Reactome (ID: R-HSA-442755) and involves 52 genes. In the BiohacksAI corpus, 118 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK1, CAMK2B, CAMK2D, CAMKK1, CAMKK2.