What compounds affect the CLEC7A (Dectin-1) signaling pathway?

273 compounds in the BiohacksAI corpus have documented interactions with genes in the CLEC7A (Dectin-1) signaling pathway (Reactome ID: R-HSA-5607764). These compounds target 47 genes within this pathway.

What genes are in the CLEC7A (Dectin-1) signaling pathway?

The CLEC7A (Dectin-1) signaling pathway involves 47 genes. Key genes include: ADRM1, CHUK, CUL1, IKBKB, IL1B, MAP3K7, NFKB1, NFKB2, NFKBIA, PDPK1.

CLEC7A (Dectin-1) signaling

REACTOME PATHWAY

Reactome: R-HSA-560776447 genes273 compounds

The CLEC7A (Dectin-1) signaling pathway (Reactome ID: R-HSA-5607764) involves 47 genes and is affected by 273 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CHUK CUL1 IKBKB IL1B MAP3K7 NFKB1 NFKB2 NFKBIA PDPK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6+17 more

Compounds Affecting CLEC7A (Dectin-1) signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	sp600125	—	117
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	alsterpaullone	—	12
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Resveratrol	—	298
9	Crizotinib	—	298
10	Disulfiram	—	297
11	Podophyllotoxin	—	14
12	withaferin	—	300
13	Kaempferols	—	300
14	kenpaullone	—	8
15	chicoric acid	—	117
16	Chlorhexidine	—	299
17	Niclosamide	—	299
18	Trifluridine	—	295
19	tyrphostin ag 1478	—	4
20	Astemizole Antihistamine drug now withdrawn from	—	280
21	Sorafenib	—	300
22	Rutin	—	300
23	Withania	—	500
24	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
25	tamarixetin	—	26
26	Dasatinib	—	299
27	cycloheximide	—	300
28	Digoxin	—	299
29	Lovastatin	—	300
30	Mometasone Furoate	—	292
31	piceatannol	—	300
32	Sertraline	—	1,000
33	Ursolic Acid	—	300
34	Afatinib	—	297
35	Beclomethasone	—	300
36	Cerulenin	—	300
37	Digitoxin	—	300
38	Hexachlorophene	—	300
39	lidoflazine	—	278
40	ly294002	—	11
41	monorden	—	8
42	Nisoldipine	—	297
43	Perphenazine	—	297
44	vinblastine sulfate	—	81
45	chrysin	—	300
46	daph	—	2
47	Ethidium	—	300
48	Fluocinolone Acetonide	—	295
49	Melengestrol Acetate	—	300
50	Hydrocortisone	—	299

About the CLEC7A (Dectin-1) signaling Pathway

The CLEC7A (Dectin-1) signaling pathway is catalogued in Reactome (ID: R-HSA-5607764) and involves 47 genes. In the BiohacksAI corpus, 273 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CHUK, CUL1, IKBKB, IL1B.