What compounds affect the Ub-specific processing proteases pathway?

480 compounds in the BiohacksAI corpus have documented interactions with genes in the Ub-specific processing proteases pathway (Reactome ID: R-HSA-5689880). These compounds target 60 genes within this pathway.

What genes are in the Ub-specific processing proteases pathway?

The Ub-specific processing proteases pathway involves 60 genes. Key genes include: ADRB2, ADRM1, AR, ARRB1, CCNA1, CDC25A, CFTR, HIF1A, IDE, KAT2A.

Ub-specific processing proteases

REACTOME PATHWAY

Reactome: R-HSA-568988060 genes480 compounds

The Ub-specific processing proteases pathway (Reactome ID: R-HSA-5689880) involves 60 genes and is affected by 480 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRB2 ADRM1 AR ARRB1 CCNA1 CDC25A CFTR HIF1A IDE KAT2A MAP3K7 MDM2 MDM4 MYC NFKBIA POLB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7+30 more

Compounds Affecting Ub-specific processing proteases

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
5	Hexachlorophene	—	300
6	Nisoldipine	—	297
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	cycloheximide	—	300
9	Dinitrochlorobenzene	—	300
10	Oxyphenbutazone	—	300
11	celastrol	—	300
12	alpha-Linolenic Acid	—	300
13	Disulfiram	—	297
14	vinblastine sulfate	—	81
15	Methylene Blue	—	200
16	Astemizole Antihistamine drug now withdrawn from	—	280
17	Nocodazole Nocodazole is	—	215
18	rafoxanide	—	172
19	Digoxin	—	299
20	Azacitidine	—	298
21	Azacitidine	—	300
22	Loratadine	—	296
23	Colchicine	—	300
24	Ciclopirox	—	88
25	Podophyllotoxin	—	14
26	chrysin	—	300
27	egcg	—	300
28	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
29	Niclosamide	—	299
30	sp600125	—	117
31	Ethidium	—	300
32	Dactinomycin	—	297
33	Chlorhexidine	—	299
34	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
35	Dasatinib	—	299
36	Emetine	—	298
37	o-Phthalaldehyde	—	300
38	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
39	Fluspirilene	—	74
40	Perphenazine	—	297
41	prunetin	—	35
42	Thioridazine	—	35
43	Cladribine	—	297
44	Anisomycin	—	247
45	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
46	Tubercidin	—	300
47	Spironolactone	—	298
48	Ethinyl Estradiol	—	300
49	Danazol	—	298
50	Clotrimazole	—	296

About the Ub-specific processing proteases Pathway

The Ub-specific processing proteases pathway is catalogued in Reactome (ID: R-HSA-5689880) and involves 60 genes. In the BiohacksAI corpus, 480 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRB2, ADRM1, AR, ARRB1, CCNA1.