What genes are in the Post-translational protein modification pathway?

The Post-translational protein modification pathway involves 214 genes. Key genes include: ADAM10, ADAMTS4, ADAMTS5, ADRB2, ADRM1, ALB, ALPG, ALPL, APP, AR.

Post-translational protein modification

Q: What compounds affect the Post-translational protein modification pathway?

778 compounds in the BiohacksAI corpus have documented interactions with genes in the Post-translational protein modification pathway (Reactome ID: R-HSA-597592). These compounds target 214 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-597592214 genes778 compounds

The Post-translational protein modification pathway (Reactome ID: R-HSA-597592) involves 214 genes and is affected by 778 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 ADAMTS4 ADAMTS5 ADRB2 ADRM1 ALB ALPG ALPL APP AR ARRB1 ARSA ASPH AURKA AURKB BAP1 BARD1 BIRC5 BLM BRCA1 CCNA1 CDC25A CDK1 CFTR COPS5 CREBBP CSNK1D CTBP1 CTSA CUL1+184 more

Compounds Affecting Post-translational protein modification

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	vinblastine sulfate	—	81
3	Podophyllotoxin	—	14
4	Nocodazole Nocodazole is	—	215
5	Colchicine	—	300
6	Quercetin	—	300
7	Hexachlorophene	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Vincristine	—	299
10	Vorinostat	—	299
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	cycloheximide	—	300
13	Reserpine	—	297
14	Demecolcine	—	246
15	Methylene Blue	—	200
16	Ethidium	—	300
17	Daunorubicin	—	298
18	Digoxin	—	299
19	Azacitidine	—	298
20	Azacitidine	—	300
21	Resveratrol	—	298
22	Niclosamide	—	299
23	Noscapine	—	300
24	Progesterone	—	299
25	Disulfiram	—	297
26	egcg	—	300
27	alpha-Linolenic Acid	—	300
28	Nisoldipine	—	297
29	Kaempferols	—	300
30	Dinitrochlorobenzene	—	300
31	Astemizole Antihistamine drug now withdrawn from	—	280
32	Genistein	—	300
33	chrysin	—	300
34	Methotrexate	—	289
35	Chlorhexidine	—	299
36	Oxyphenbutazone	—	300
37	sp600125	—	117
38	Dactinomycin	—	297
39	Clotrimazole	—	296
40	Celecoxib	—	295
41	Dasatinib	—	299
42	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
43	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
44	rafoxanide	—	172
45	Maytansine	—	300
46	Spironolactone	—	298
47	Loratadine	—	296
48	candesartan cilexetil [Supplementary Concept]	—	300
49	Emetine	—	298
50	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300

About the Post-translational protein modification Pathway

The Post-translational protein modification pathway is catalogued in Reactome (ID: R-HSA-597592) and involves 214 genes. In the BiohacksAI corpus, 778 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ADAMTS4, ADAMTS5, ADRB2, ADRM1.