What genes are in the Platelet activation, signaling and aggregation pathway?

The Platelet activation, signaling and aggregation pathway involves 50 genes. Key genes include: ABCC4, ADRA2A, ADRA2B, ADRA2C, ALB, APP, ARRB1, CDC42, CFL1, CSK.

Platelet activation, signaling and aggregation

Q: What compounds affect the Platelet activation, signaling and aggregation pathway?

408 compounds in the BiohacksAI corpus have documented interactions with genes in the Platelet activation, signaling and aggregation pathway (Reactome ID: R-HSA-76002). These compounds target 50 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-7600250 genes408 compounds

The Platelet activation, signaling and aggregation pathway (Reactome ID: R-HSA-76002) involves 50 genes and is affected by 408 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC4 ADRA2A ADRA2B ADRA2C ALB APP ARRB1 CDC42 CFL1 CSK F13A1 F5 FYN GNA15 GNAI1 GP6 GRB2 HSPA5 ITGA2B ITGB3 LAT LCK LYN MAPK1 MAPK14 MAPK3 MGLL P2RY1 P2RY12 PDPK1+20 more

Compounds Affecting Platelet activation, signaling and aggregation

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	kenpaullone	—	8
3	Dasatinib	—	299
4	tyrphostin ag 1478	—	4
5	Quercetin	—	300
6	alsterpaullone	—	12
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	Crizotinib	—	298
9	Aripiprazole	—	298
10	Hexachlorophene	—	300
11	ly294002	—	11
12	Perphenazine	—	297
13	pictilisib	—	25
14	Amoxapine	—	259
15	Sirolimus	—	300
16	sp600125	—	117
17	cbd	—	298
18	Afatinib	—	297
19	cannabidiol	—	296
20	Clotrimazole	—	296
21	Idarubicin	—	299
22	Metergoline	—	144
23	Fluspirilene	—	74
24	egcg	—	300
25	Chlorhexidine	—	299
26	Niclosamide	—	299
27	alpelisib	—	227
28	Axitinib	—	298
29	Maprotiline	—	299
30	withaferin	—	300
31	Methylene Blue	—	200
32	Sertraline	—	1,000
33	Astemizole Antihistamine drug now withdrawn from	—	280
34	Daunorubicin	—	298
35	lidoflazine	—	278
36	Nortriptyline	—	295
37	Fluoxetine	—	1,000
38	Buspirone	—	299
39	Methysergide	—	300
40	pd98059	—	7
41	Pramipexole	—	297
42	Bromocriptine	—	299
43	Carvedilol	—	296
44	Trazodone	—	297
45	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
46	Arachidonic Acid	—	245
47	Resveratrol	—	298
48	Evans Blue	—	300
49	Wortmannin	—	300
50	Disulfiram	—	297

About the Platelet activation, signaling and aggregation Pathway

The Platelet activation, signaling and aggregation pathway is catalogued in Reactome (ID: R-HSA-76002) and involves 50 genes. In the BiohacksAI corpus, 408 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC4, ADRA2A, ADRA2B, ADRA2C, ALB.