What compounds affect the Extra-nuclear estrogen signaling pathway?

376 compounds in the BiohacksAI corpus have documented interactions with genes in the Extra-nuclear estrogen signaling pathway (Reactome ID: R-HSA-9009391). These compounds target 25 genes within this pathway.

What genes are in the Extra-nuclear estrogen signaling pathway?

The Extra-nuclear estrogen signaling pathway involves 25 genes. Key genes include: AKT3, CREB1, EGFR, ESR1, ESR2, FOS, FOXO3, GNAI1, HSP90AA1, HSPB1.

Extra-nuclear estrogen signaling

REACTOME PATHWAY

Reactome: R-HSA-900939125 genes376 compounds

The Extra-nuclear estrogen signaling pathway (Reactome ID: R-HSA-9009391) involves 25 genes and is affected by 376 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 CREB1 EGFR ESR1 ESR2 FOS FOXO3 GNAI1 HSP90AA1 HSPB1 IGF1R MAPK1 MAPK3 MMP7 NOS3 PDPK1 PIK3R1 PIK3R2 PIK3R3 PRKCZ PRMT1 S1PR3 SPHK1 SRC XPO1

Compounds Affecting Extra-nuclear estrogen signaling

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Masoprocol	—	300
3	Ethidium	—	300
4	Ciclopirox	—	88
5	Clotrimazole	—	296
6	Nisoldipine	—	297
7	Dasatinib	—	299
8	Disulfiram	—	297
9	alsterpaullone	—	12
10	Resveratrol	—	298
11	Ethinyl Estradiol	—	300
12	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
13	Danazol	—	298
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	Hexachlorophene	—	300
16	Bortezomib	—	300
17	Daunorubicin	—	298
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	tyrphostin ag 1478	—	4
20	kenpaullone	—	8
21	ly294002	—	11
22	Genistein	—	300
23	Dactinomycin	—	297
24	Oxymetholone	—	298
25	cycloheximide	—	300
26	Progesterone	—	299
27	Vitamin	—	295
28	vinblastine sulfate	—	81
29	Loratadine	—	296
30	Toxaphene	—	299
31	chrysin	—	300
32	Testosterone	—	299
33	Emetine	—	298
34	o-Phthalaldehyde	—	300
35	Troglitazone	—	299
36	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
37	Demeclocycline	—	5
38	Sulbactam	—	299
39	Tetracycline	—	300
40	Lithocholic Acid	—	300
41	trequinsin hydrochloride	—	1
42	Calcimycin	—	216
43	plumbagin [Supplementary Concept]	—	300
44	Sorafenib	—	300
45	Sirolimus	—	300
46	Levonorgestrel	—	292
47	Norgestrel	—	300
48	Methyltestosterone	—	300
49	Dehydroepiandrosterone	—	300
50	Dehydroepiandrosterone	—	300

About the Extra-nuclear estrogen signaling Pathway

The Extra-nuclear estrogen signaling pathway is catalogued in Reactome (ID: R-HSA-9009391) and involves 25 genes. In the BiohacksAI corpus, 376 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, CREB1, EGFR, ESR1, ESR2.