What genes are in the Leishmania parasite growth and survival pathway?

The Leishmania parasite growth and survival pathway involves 23 genes. Key genes include: ADAM17, ADCY9, ADORA2B, CREB1, CYSLTR1, CYSLTR2, FGR, FURIN, FYN, GNAI1.

Leishmania parasite growth and survival

Q: What compounds affect the Leishmania parasite growth and survival pathway?

269 compounds in the BiohacksAI corpus have documented interactions with genes in the Leishmania parasite growth and survival pathway (Reactome ID: R-HSA-9664433). These compounds target 23 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-966443323 genes269 compounds

The Leishmania parasite growth and survival pathway (Reactome ID: R-HSA-9664433) involves 23 genes and is affected by 269 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM17 ADCY9 ADORA2B CREB1 CYSLTR1 CYSLTR2 FGR FURIN FYN GNAI1 GNAS HCK IL6 LYN MAPK14 PLK2 PRKACA PRKACB PRKACG PRKX SRC SYK YES1

Compounds Affecting Leishmania parasite growth and survival

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	tyrphostin ag 1478	—	4
3	Sorafenib	—	300
4	Crizotinib	—	298
5	Quercetin	—	300
6	Afatinib	—	297
7	kenpaullone	—	8
8	hydroxyfasudil [Supplementary Concept]	—	11
9	Disulfiram	—	297
10	Niclosamide	—	299
11	Axitinib	—	298
12	Cladribine	—	297
13	Daunorubicin	—	298
14	Kaempferols	—	300
15	alsterpaullone	—	12
16	Ethidium	—	300
17	sp600125	—	117
18	Clofarabine	—	298
19	cycloheximide	—	300
20	Emetine	—	298
21	fisetin	—	78
22	alpelisib	—	227
23	Bortezomib	—	300
24	Nocodazole Nocodazole is	—	215
25	withaferin	—	300
26	Danazol	—	298
27	Ethinyl Estradiol	—	300
28	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
29	monorden	—	8
30	Nisoldipine	—	297
31	pictilisib	—	25
32	Tilorone	—	300
33	trequinsin hydrochloride	—	1
34	Vemurafenib	—	298
35	chrysin	—	300
36	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
37	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
38	Azacitidine	—	298
39	Azacitidine	—	300
40	Ciclopirox	—	88
41	Edaravone	—	298
42	Idarubicin	—	299
43	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
44	Adenosine Monophosphate Adenine nucleotide containing	—	300
45	Genistein	—	300
46	Aurintricarboxylic Acid	—	184
47	Rosmarinic Acid	—	300
48	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
49	egcg	—	300
50	Leukotriene E4	—	300

About the Leishmania parasite growth and survival Pathway

The Leishmania parasite growth and survival pathway is catalogued in Reactome (ID: R-HSA-9664433) and involves 23 genes. In the BiohacksAI corpus, 269 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM17, ADCY9, ADORA2B, CREB1, CYSLTR1.