What compounds affect the SARS-CoV-1 Infection pathway?

150 compounds in the BiohacksAI corpus have documented interactions with genes in the SARS-CoV-1 Infection pathway (Reactome ID: R-HSA-9678108). These compounds target 31 genes within this pathway.

What genes are in the SARS-CoV-1 Infection pathway?

The SARS-CoV-1 Infection pathway involves 31 genes. Key genes include: BCL2L1, CASP1, CTSL, EP300, FKBP1A, GALNT1, GANAB, GSK3A, GSK3B, HNRNPA1.

SARS-CoV-1 Infection

REACTOME PATHWAY

Reactome: R-HSA-967810831 genes150 compounds

The SARS-CoV-1 Infection pathway (Reactome ID: R-HSA-9678108) involves 31 genes and is affected by 150 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BCL2L1 CASP1 CTSL EP300 FKBP1A GALNT1 GANAB GSK3A GSK3B HNRNPA1 IKBKE KPNB1 MAP1LC3B NFKB1 NFKBIA NLRP3 NPM1 PDPK1 PIK3C3 PKLR PSMC6 RELA RIPK3 RPSA RUNX1 SMAD3 SUMO1 TBK1 VCP YWHAB+1 more

Compounds Affecting SARS-CoV-1 Infection

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	egcg	—	300
3	Hexachlorophene	—	300
4	Disulfiram	—	297
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Kaempferols	—	300
7	Bortezomib	—	300
8	alsterpaullone	—	12
9	kenpaullone	—	8
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	cycloheximide	—	300
12	Podophyllotoxin	—	14
13	vinblastine sulfate	—	81
14	chrysin	—	300
15	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
16	Ethinyl Estradiol	—	300
17	Masoprocol	—	300
18	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
19	Rutin	—	300
20	Chlorhexidine	—	299
21	sp600125	—	117
22	Oxytetracycline	—	300
23	Crizotinib	—	298
24	Anisomycin	—	247
25	Ethidium	—	300
26	Daunorubicin	—	298
27	Domperidone	—	299
28	Promethazine	—	121
29	streptonigrin	—	299
30	Resveratrol	—	298
31	Withania	—	500
32	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
33	ly294002	—	11
34	tamarixetin	—	26
35	Triamcinolone	—	300
36	Trifluridine	—	295
37	withaferin	—	300
38	plumbagin [Supplementary Concept]	—	300
39	Ursolic Acid	—	300
40	chicoric acid	—	117
41	Oleanolic Acid	—	300
42	Thioridazine	—	35
43	indirubin	—	300
44	fisetin	—	78
45	Aurintricarboxylic Acid	—	184
46	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
47	amlexanox	—	96
48	Calcimycin	—	216
49	Azacitidine	—	298
50	Azacitidine	—	300

About the SARS-CoV-1 Infection Pathway

The SARS-CoV-1 Infection pathway is catalogued in Reactome (ID: R-HSA-9678108) and involves 31 genes. In the BiohacksAI corpus, 150 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BCL2L1, CASP1, CTSL, EP300, FKBP1A.