What compounds affect the KEAP1-NFE2L2 pathway pathway?

328 compounds in the BiohacksAI corpus have documented interactions with genes in the KEAP1-NFE2L2 pathway pathway (Reactome ID: R-HSA-9755511). These compounds target 61 genes within this pathway.

What genes are in the KEAP1-NFE2L2 pathway pathway?

The KEAP1-NFE2L2 pathway pathway involves 61 genes. Key genes include: ABCC1, ABCC3, ABCG2, ADRM1, AKT3, BCL2L1, BRCA1, CCL2, CREBBP, CSNK2A1.

KEAP1-NFE2L2 pathway

REACTOME PATHWAY

Reactome: R-HSA-975551161 genes328 compounds

The KEAP1-NFE2L2 pathway pathway (Reactome ID: R-HSA-9755511) involves 61 genes and is affected by 328 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ABCC3 ABCG2 ADRM1 AKT3 BCL2L1 BRCA1 CCL2 CREBBP CSNK2A1 CSNK2A2 CSNK2B CUL1 EIF2AK3 EP300 G6PD GSK3B GSR IDH1 MAP1LC3B MYC NFE2L2 NFKB1 NQO1 PGD PRDX1 PRKAA2 PSMA1 PSMA2 PSMA3+31 more

Compounds Affecting KEAP1-NFE2L2 pathway

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Kaempferols	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	chrysin	—	300
8	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
9	ly294002	—	11
10	egcg	—	300
11	vinblastine sulfate	—	81
12	Hexachlorophene	—	300
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Resveratrol	—	298
15	Niclosamide	—	299
16	Podophyllotoxin	—	14
17	Methotrexate	—	289
18	Oleanolic Acid	—	300
19	Trifluridine	—	295
20	Rutin	—	300
21	fisetin	—	78
22	Colchicine	—	300
23	Azacitidine	—	298
24	Azacitidine	—	300
25	Genistein	—	300
26	Methylene Blue	—	200
27	Nocodazole Nocodazole is	—	215
28	ninhydrin	—	300
29	Daunorubicin	—	298
30	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
31	sp600125	—	117
32	Disulfiram	—	297
33	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
34	candesartan cilexetil [Supplementary Concept]	—	300
35	Chlorhexidine	—	299
36	Lovastatin	—	300
37	Triamcinolone	—	300
38	Delavirdine	—	296
39	Ursolic Acid	—	300
40	Vanillic Acid	—	300
41	Rotenone	—	300
42	Azathioprine	—	300
43	alyssin [Supplementary Concept]	—	300
44	Digitoxin	—	300
45	Digoxin	—	299
46	Vitamin K 3	—	300
47	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
48	Axitinib	—	298
49	Dinitrochlorobenzene	—	300
50	Nisoldipine	—	297

About the KEAP1-NFE2L2 pathway Pathway

The KEAP1-NFE2L2 pathway pathway is catalogued in Reactome (ID: R-HSA-9755511) and involves 61 genes. In the BiohacksAI corpus, 328 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ABCC3, ABCG2, ADRM1, AKT3.