What genes are in the Response of endothelial cells to shear stress pathway?

The Response of endothelial cells to shear stress pathway involves 36 genes. Key genes include: ABL1, ADCY9, ANXA2, CHUK, FLT4, FYN, GNAS, IKBKB, IKBKE, ITGAV.

Response of endothelial cells to shear stress

Q: What compounds affect the Response of endothelial cells to shear stress pathway?

186 compounds in the BiohacksAI corpus have documented interactions with genes in the Response of endothelial cells to shear stress pathway (Reactome ID: R-HSA-9860931). These compounds target 36 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-986093136 genes186 compounds

The Response of endothelial cells to shear stress pathway (Reactome ID: R-HSA-9860931) involves 36 genes and is affected by 186 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADCY9 ANXA2 CHUK FLT4 FYN GNAS IKBKB IKBKE ITGAV ITGB3 KDR MAPKAP1 MLST8 MMP14 MTOR NFKB1 NFKBIA NOS3 P2RY2 PANX1 PDE4D PDPK1 PIK3CB PIK3CD PIK3R2 PKN2 PPP2CA PRKACA PRKACB+6 more

Compounds Affecting Response of endothelial cells to shear stress

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Resveratrol	—	298
3	ly294002	—	11
4	Sirolimus	—	300
5	torin 1	—	10
6	Ku 0063794 [Supplementary Concept]	—	7
7	alpelisib	—	227
8	alsterpaullone	—	12
9	kenpaullone	—	8
10	Quercetin	—	300
11	egcg	—	300
12	pictilisib	—	25
13	chicoric acid	—	117
14	Sorafenib	—	300
15	Axitinib	—	298
16	Dasatinib	—	299
17	sp600125	—	117
18	hydroxyfasudil [Supplementary Concept]	—	11
19	Podophyllotoxin	—	14
20	Genistein	—	300
21	Disulfiram	—	297
22	tyrphostin ag 1478	—	4
23	Wortmannin	—	300
24	Ursolic Acid	—	300
25	Adenosine Triphosphate	—	300
26	Rotenone	—	300
27	Camptothecin	—	300
28	Thapsigargin	—	300
29	celastrol	—	300
30	Emetine	—	298
31	Nocodazole Nocodazole is	—	215
32	tyrphostin 9	—	2
33	Bortezomib	—	300
34	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
35	Kaempferols	—	300
36	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
37	Rutin	—	300
38	Withania	—	500
39	Hexachlorophene	—	300
40	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
41	streptonigrin	—	299
42	tamarixetin	—	26
43	Trifluridine	—	295
44	tyrphostin 1	—	1
45	withaferin	—	300
46	Everolimus	—	297
47	Niclosamide	—	299
48	triolimus [Supplementary Concept]	—	33
49	Oleanolic Acid	—	300
50	Avapritinib	—	246

About the Response of endothelial cells to shear stress Pathway

The Response of endothelial cells to shear stress pathway is catalogued in Reactome (ID: R-HSA-9860931) and involves 36 genes. In the BiohacksAI corpus, 186 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADCY9, ANXA2, CHUK, FLT4.