What compounds affect the Regulation of PD-L1(CD274) expression pathway?

339 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of PD-L1(CD274) expression pathway (Reactome ID: R-HSA-9909648). These compounds target 75 genes within this pathway.

What genes are in the Regulation of PD-L1(CD274) expression pathway?

The Regulation of PD-L1(CD274) expression pathway involves 75 genes. Key genes include: ADRM1, AGO2, ASH2L, BRD4, CDK4, COPS5, CREBBP, CSNK2A1, CSNK2A2, CSNK2B.

Regulation of PD-L1(CD274) expression

REACTOME PATHWAY

Reactome: R-HSA-990964875 genes339 compounds

The Regulation of PD-L1(CD274) expression pathway (Reactome ID: R-HSA-9909648) involves 75 genes and is affected by 339 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 ASH2L BRD4 CDK4 COPS5 CREBBP CSNK2A1 CSNK2A2 CSNK2B CUL1 DPY30 EED EP300 EPAS1 EZH2 FOS GSK3B HIF1A JUN KMT2A MYC NEK2 NFE2L2 NFKB1 NFKB2 PRKAA1 PRKAA2 PRKAB1 PRKAB2+45 more

Compounds Affecting Regulation of PD-L1(CD274) expression

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Rotenone	—	300
6	Niclosamide	—	299
7	Kaempferols	—	300
8	Oleanolic Acid	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Antimycin	—	300
11	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
12	Ursolic Acid	—	300
13	egcg	—	300
14	Berberine	—	300
15	chrysin	—	300
16	ly294002	—	11
17	Adenosine Monophosphate Adenine nucleotide containing	—	300
18	Proguanil	—	299
19	Metformin	—	1,000
20	Resveratrol	—	298
21	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
22	s adenosylhomocysteine	—	300
23	Podophyllotoxin	—	14
24	sp600125	—	117
25	Rutin	—	300
26	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
27	Colchicine	—	300
28	Hexachlorophene	—	300
29	Nocodazole Nocodazole is	—	215
30	ninhydrin	—	300
31	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
32	Clotrimazole	—	296
33	Disulfiram	—	297
34	Masoprocol	—	300
35	fisetin	—	78
36	Genistein	—	300
37	Methylene Blue	—	200
38	Ethoxyquin Antioxidant; also	—	180
39	vinblastine sulfate	—	81
40	Digoxin	—	299
41	DEAD-box RNA Helicases	—	169
42	Thioctic Acid	—	298
43	Oxyphenbutazone	—	300
44	Thioctic Acid	—	300
45	Nisoldipine	—	297
46	Budesonide	—	1,000
47	Phenoxybenzamine	—	21
48	Hydrocortisone	—	299
49	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
50	Cetylpyridinium Cationic bactericidal surfactant used as	—	300

About the Regulation of PD-L1(CD274) expression Pathway

The Regulation of PD-L1(CD274) expression pathway is catalogued in Reactome (ID: R-HSA-9909648) and involves 75 genes. In the BiohacksAI corpus, 339 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, ASH2L, BRD4, CDK4.