What compounds affect the MyD88-independent TLR4 cascade pathway?

280 compounds in the BiohacksAI corpus have documented interactions with genes in the MyD88-independent TLR4 cascade pathway (Reactome ID: R-HSA-166166). These compounds target 42 genes within this pathway.

What genes are in the MyD88-independent TLR4 cascade pathway?

The MyD88-independent TLR4 cascade pathway involves 42 genes. Key genes include: APP, CHUK, CREB1, CUL1, DUSP3, FOS, HMGB1, IKBKB, IKBKE, IRAK1.

MyD88-independent TLR4 cascade

REACTOME PATHWAY

Reactome: R-HSA-16616642 genes280 compounds

The MyD88-independent TLR4 cascade pathway (Reactome ID: R-HSA-166166) involves 42 genes and is affected by 280 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP CHUK CREB1 CUL1 DUSP3 FOS HMGB1 IKBKB IKBKE IRAK1 JUN MAP2K1 MAP2K3 MAP2K4 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 NFKB1 NFKB2 NFKBIA NOD1 NOD2 PPP2CA+12 more

Compounds Affecting MyD88-independent TLR4 cascade

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	sp600125	—	117
3	Quercetin	—	300
4	withaferin	—	300
5	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
6	Crizotinib	—	298
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Disulfiram	—	297
9	Axitinib	—	298
10	Afatinib	—	297
11	Anisomycin	—	247
12	Resveratrol	—	298
13	Dasatinib	—	299
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	fisetin	—	78
16	Bortezomib	—	300
17	Oxyphenbutazone	—	300
18	Kaempferols	—	300
19	Trifluridine	—	295
20	plumbagin [Supplementary Concept]	—	300
21	cycloheximide	—	300
22	Digitoxin	—	300
23	Digoxin	—	299
24	pd98059	—	7
25	egcg	—	300
26	Podophyllotoxin	—	14
27	alsterpaullone	—	12
28	chicoric acid	—	117
29	pictilisib	—	25
30	Vemurafenib	—	298
31	Hexachlorophene	—	300
32	Methylene Blue	—	200
33	Cladribine	—	297
34	ninhydrin	—	300
35	Camptothecin	—	300
36	Genistein	—	300
37	daph	—	2
38	Clotrimazole	—	296
39	Thioridazine	—	35
40	vinblastine sulfate	—	81
41	Nisoldipine	—	297
42	Nocodazole Nocodazole is	—	215
43	Sertraline	—	1,000
44	Adenosine Triphosphate	—	300
45	Salmeterol Xinafoate	—	227
46	Masoprocol	—	300
47	Rutin	—	300
48	Withania	—	500
49	tamarixetin	—	26
50	tyrphostin ag 1478	—	4

About the MyD88-independent TLR4 cascade Pathway

The MyD88-independent TLR4 cascade pathway is catalogued in Reactome (ID: R-HSA-166166) and involves 42 genes. In the BiohacksAI corpus, 280 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, CHUK, CREB1, CUL1, DUSP3.