What compounds affect the Signaling by VEGF pathway?

125 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by VEGF pathway (Reactome ID: R-HSA-194138). These compounds target 36 genes within this pathway.

What genes are in the Signaling by VEGF pathway?

The Signaling by VEGF pathway involves 36 genes. Key genes include: AKT3, AXL, CDC42, CYBB, FLT1, FLT4, FYN, HSP90AA1, HSPB1, ITGAV.

Signaling by VEGF

REACTOME PATHWAY

Reactome: R-HSA-19413836 genes125 compounds

The Signaling by VEGF pathway (Reactome ID: R-HSA-194138) involves 36 genes and is affected by 125 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 AXL CDC42 CYBB FLT1 FLT4 FYN HSP90AA1 HSPB1 ITGAV ITGB3 KDR MAPK11 MAPK12 MAPK13 MAPK14 MAPKAP1 MAPKAPK2 MLST8 MTOR NCF1 NOS3 NRP2 PDPK1 PIK3CB PIK3R1 PIK3R2 PRKACA PRKACB PRKACG+6 more

Compounds Affecting Signaling by VEGF

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Quercetin	—	300
3	Crizotinib	—	298
4	kenpaullone	—	8
5	Dasatinib	—	299
6	sp600125	—	117
7	Sirolimus	—	300
8	torin 1	—	10
9	Afatinib	—	297
10	alsterpaullone	—	12
11	hydroxyfasudil [Supplementary Concept]	—	11
12	Wortmannin	—	300
13	pictilisib	—	25
14	ly294002	—	11
15	Ku 0063794 [Supplementary Concept]	—	7
16	alpelisib	—	227
17	Anisomycin	—	247
18	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
19	withaferin	—	300
20	Axitinib	—	298
21	Disulfiram	—	297
22	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
23	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
24	egcg	—	300
25	tyrphostin ag 1478	—	4
26	Sphingosine	—	300
27	Hexachlorophene	—	300
28	Clotrimazole	—	296
29	Ciclopirox	—	88
30	Idazoxan	—	300
31	Masoprocol	—	300
32	triolimus [Supplementary Concept]	—	33
33	monorden	—	8
34	celastrol	—	300
35	Calcimycin	—	216
36	cycloheximide	—	300
37	Idarubicin	—	299
38	Everolimus	—	297
39	Niclosamide	—	299
40	Resveratrol	—	298
41	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
42	Vitamin	—	295
43	Bufotenin	—	93
44	Feprazone	—	63
45	Nocodazole Nocodazole is	—	215
46	Phenoxybenzamine	—	21
47	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
48	Adapalene	—	296
49	alpha-Linolenic Acid	—	300
50	Bortezomib	—	300

About the Signaling by VEGF Pathway

The Signaling by VEGF pathway is catalogued in Reactome (ID: R-HSA-194138) and involves 36 genes. In the BiohacksAI corpus, 125 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, AXL, CDC42, CYBB, FLT1.