What compounds affect the PPARA activates gene expression pathway?

381 compounds in the BiohacksAI corpus have documented interactions with genes in the PPARA activates gene expression pathway (Reactome ID: R-HSA-1989781). These compounds target 29 genes within this pathway.

What genes are in the PPARA activates gene expression pathway?

The PPARA activates gene expression pathway involves 29 genes. Key genes include: AHR, ARNT, CARM1, CCNC, CDK19, CDK8, CPT2, CREBBP, CYP1A1, EP300.

PPARA activates gene expression

REACTOME PATHWAY

Reactome: R-HSA-198978129 genes381 compounds

The PPARA activates gene expression pathway (Reactome ID: R-HSA-1989781) involves 29 genes and is affected by 381 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AHR ARNT CARM1 CCNC CDK19 CDK8 CPT2 CREBBP CYP1A1 EP300 ESRRA HDAC3 HMGCR NCOA1 NCOA3 NCOR1 NCOR2 NR1D1 NR1H2 NR1H3 NR1H4 PPARA PPARG RORA RXRA RXRB SREBF1 SREBF2 UGT1A9

Compounds Affecting PPARA activates gene expression

#	Compound	Targets Hit	Studies
1	Methylene Blue	—	200
2	Gemfibrozil	—	297
3	Genistein	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Methotrexate	—	289
6	cycloheximide	—	300
7	Ethidium	—	300
8	Progesterone	—	299
9	chrysin	—	300
10	Quercetin	—	300
11	Nocodazole Nocodazole is	—	215
12	Thyroxine	—	994
13	Thyroxine	—	300
14	Resveratrol	—	298
15	Rotenone	—	300
16	Azacitidine	—	298
17	Azacitidine	—	300
18	Clotrimazole	—	296
19	Edaravone	—	298
20	Podophyllotoxin	—	14
21	trequinsin hydrochloride	—	1
22	Atorvastatin	—	1,000
23	Retinaldehyde	—	300
24	Troglitazone	—	299
25	Kaempferols	—	300
26	Dactinomycin	—	297
27	Daunorubicin	—	298
28	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
29	vinblastine sulfate	—	81
30	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
31	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
32	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
33	Disulfiram	—	297
34	Niclosamide	—	299
35	Dihydrotestosterone	—	300
36	Simvastatin	—	1,000
37	Fenofibrate	—	297
38	Loratadine	—	296
39	Spironolactone	—	298
40	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
41	Dasatinib	—	299
42	Digoxin	—	299
43	Ezetimibe	—	296
44	Dinitrochlorobenzene	—	300
45	Imatinib Mesylate	—	300
46	Nitrofurazone	—	300
47	Colchicine	—	300
48	Niflumic Acid	—	300
49	Sulindac	—	297
50	Thioridazine	—	35

About the PPARA activates gene expression Pathway

The PPARA activates gene expression pathway is catalogued in Reactome (ID: R-HSA-1989781) and involves 29 genes. In the BiohacksAI corpus, 381 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AHR, ARNT, CARM1, CCNC, CDK19.