What compounds affect the Membrane Trafficking pathway?

302 compounds in the BiohacksAI corpus have documented interactions with genes in the Membrane Trafficking pathway (Reactome ID: R-HSA-199991). These compounds target 66 genes within this pathway.

What genes are in the Membrane Trafficking pathway?

The Membrane Trafficking pathway involves 66 genes. Key genes include: AAK1, ADRB2, AGTR1, AKT3, APP, ARRB1, AVPR2, CFTR, CHRM2, COPS5.

Membrane Trafficking

REACTOME PATHWAY

Reactome: R-HSA-19999166 genes302 compounds

The Membrane Trafficking pathway (Reactome ID: R-HSA-199991) involves 66 genes and is affected by 302 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AAK1 ADRB2 AGTR1 AKT3 APP ARRB1 AVPR2 CFTR CHRM2 COPS5 CSNK1D CYTH2 EGFR F5 FOLR1 GAK GALNT1 GALNT2 GJB2 GRB2 GRIA1 GRK2 HSPA8 INS KIFC1 MAN2A1 MAP1LC3B NEDD8 PAFAH1B2 PAFAH1B3+36 more

Compounds Affecting Membrane Trafficking

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Podophyllotoxin	—	14
4	Noscapine	—	300
5	Vorinostat	—	299
6	vinblastine sulfate	—	81
7	Vincristine	—	299
8	Demecolcine	—	246
9	Maytansine	—	300
10	Niclosamide	—	299
11	Adenosine Monophosphate Adenine nucleotide containing	—	300
12	Quercetin	—	300
13	Proguanil	—	299
14	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
15	Berberine	—	300
16	Ursolic Acid	—	300
17	Antimycin	—	300
18	Oleanolic Acid	—	300
19	Rotenone	—	300
20	Metformin	—	1,000
21	Disulfiram	—	297
22	Aripiprazole	—	298
23	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
24	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
25	Kaempferols	—	300
26	pictilisib	—	25
27	Chlorhexidine	—	299
28	Nadolol	—	297
29	Carvedilol	—	296
30	Hexachlorophene	—	300
31	Astemizole Antihistamine drug now withdrawn from	—	280
32	Clotrimazole	—	296
33	Amoxapine	—	259
34	kenpaullone	—	8
35	Ethidium	—	300
36	Methylene Blue	—	200
37	alsterpaullone	—	12
38	Digoxin	—	299
39	Axitinib	—	298
40	candesartan cilexetil [Supplementary Concept]	—	300
41	Dasatinib	—	299
42	Afatinib	—	297
43	Crizotinib	—	298
44	Oxytetracycline	—	300
45	sp600125	—	117
46	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
47	Terbutaline	—	299
48	Hydroxyzine	—	298
49	Loratadine	—	296
50	Nicergoline	—	300

About the Membrane Trafficking Pathway

The Membrane Trafficking pathway is catalogued in Reactome (ID: R-HSA-199991) and involves 66 genes. In the BiohacksAI corpus, 302 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AAK1, ADRB2, AGTR1, AKT3, APP.