What genes are in the Cytochrome P450 - arranged by substrate type pathway?

The Cytochrome P450 - arranged by substrate type pathway involves 31 genes. Key genes include: AHR, ARNT, CYP11B1, CYP11B2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP24A1, CYP2A13.

Cytochrome P450 - arranged by substrate type

Q: What compounds affect the Cytochrome P450 - arranged by substrate type pathway?

669 compounds in the BiohacksAI corpus have documented interactions with genes in the Cytochrome P450 - arranged by substrate type pathway (Reactome ID: R-HSA-211897). These compounds target 31 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-21189731 genes669 compounds

The Cytochrome P450 - arranged by substrate type pathway (Reactome ID: R-HSA-211897) involves 31 genes and is affected by 669 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AHR ARNT CYP11B1 CYP11B2 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP24A1 CYP2A13 CYP2A6 CYP2B6 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2J2 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP3A7-CYP3A51P CYP46A1 CYP51A1 CYP8B1 NCOA1 NR1H4 POR RXRA+1 more

Compounds Affecting Cytochrome P450 - arranged by substrate type

#	Compound	Targets Hit	Studies
1	Clotrimazole	—	296
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Miconazole	—	298
4	Quercetin	—	300
5	Methylene Blue	—	200
6	Ethidium	—	300
7	Methoxsalen	—	300
8	Vitamin K 3	—	300
9	chrysin	—	300
10	Kaempferols	—	300
11	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
12	Voriconazole	—	299
13	cbd	—	298
14	cannabidiol	—	296
15	Ritonavir	—	298
16	Disulfiram	—	297
17	Ethinyl Estradiol	—	300
18	Flutamide	—	298
19	Rotenone	—	300
20	Chlorhexidine	—	299
21	Nisoldipine	—	297
22	Danazol	—	298
23	Reserpine	—	297
24	Simvastatin	—	1,000
25	Niclosamide	—	299
26	Carbaryl	—	300
27	Genistein	—	300
28	Sulindac	—	297
29	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
30	Pueraria	—	300
31	Melphalan	—	300
32	Nitrofurazone	—	300
33	Phenelzine	—	2
34	Piperonyl Butoxide	—	300
35	Podophyllotoxin	—	14
36	Fluvoxamine	—	297
37	Troglitazone	—	299
38	amlexanox	—	96
39	Amoxapine	—	259
40	Axitinib	—	298
41	Dihydrotestosterone	—	300
42	Edaravone	—	298
43	Retinaldehyde	—	300
44	trequinsin hydrochloride	—	1
45	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
46	Kaempferols	—	300
47	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
48	Isoniazid Antibacterial agent used primarily as	—	299
49	Levonorgestrel	—	292
50	Norgestrel	—	300

About the Cytochrome P450 - arranged by substrate type Pathway

The Cytochrome P450 - arranged by substrate type pathway is catalogued in Reactome (ID: R-HSA-211897) and involves 31 genes. In the BiohacksAI corpus, 669 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AHR, ARNT, CYP11B1, CYP11B2, CYP19A1.