What compounds affect the Signaling by GPCR pathway?

749 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by GPCR pathway (Reactome ID: R-HSA-372790). These compounds target 255 genes within this pathway.

What genes are in the Signaling by GPCR pathway?

The Signaling by GPCR pathway involves 255 genes. Key genes include: ADCY9, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1.

Signaling by GPCR

REACTOME PATHWAY

Reactome: R-HSA-372790255 genes749 compounds

The Signaling by GPCR pathway (Reactome ID: R-HSA-372790) involves 255 genes and is affected by 749 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGTR1 AGTR2 AKT3 APLNR APP ARRB1 AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BTK C5 CALCR CAMK2B CAMK2D CAMKK1 CAMKK2+225 more

Compounds Affecting Signaling by GPCR

#	Compound	Targets Hit	Studies
1	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
2	Aripiprazole	—	298
3	Astemizole Antihistamine drug now withdrawn from	—	280
4	Metergoline	—	144
5	Carvedilol	—	296
6	Perphenazine	—	297
7	Fluspirilene	—	74
8	Amoxapine	—	259
9	Chlorhexidine	—	299
10	Loxapine	—	225
11	Quetiapine Fumarate	—	994
12	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
13	Mianserin	—	299
14	Fluoxetine	—	1,000
15	Cyproheptadine	—	299
16	Dihydroergotamine	—	299
17	Nortriptyline	—	295
18	Dihydroergotamine	—	9
19	Pergolide	—	299
20	Bromocriptine	—	299
21	Lisuride	—	299
22	Calcimycin	—	216
23	Yohimbine	—	299
24	Promethazine	—	296
25	Clotrimazole	—	296
26	Hexachlorophene	—	300
27	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
28	Maprotiline	—	299
29	Hydroxyzine	—	298
30	Disulfiram	—	297
31	Methysergide	—	300
32	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
33	Buspirone	—	299
34	Trazodone	—	297
35	Thioridazine	—	35
36	Cabergoline	—	299
37	Methylergonovine	—	193
38	Epinephrine	—	299
39	Norepinephrine Precursor of epinephrine that is secreted by	—	298
40	cbd	—	298
41	cannabidiol	—	296
42	Domperidone	—	299
43	Duloxetine Hydrochloride	—	993
44	Ergotamine	—	299
45	Quercetin	—	300
46	Nicergoline	—	300
47	oxatomide [Supplementary Concept] structure;	—	128
48	Amlodipine	—	1,000
49	Phenylephrine	—	299
50	Tamsulosin	—	298

About the Signaling by GPCR Pathway

The Signaling by GPCR pathway is catalogued in Reactome (ID: R-HSA-372790) and involves 255 genes. In the BiohacksAI corpus, 749 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, ADORA2B, ADORA3, ADRA1A, ADRA1B.