What compounds affect the Nuclear Receptor transcription pathway pathway?

595 compounds in the BiohacksAI corpus have documented interactions with genes in the Nuclear Receptor transcription pathway pathway (Reactome ID: R-HSA-383280). These compounds target 42 genes within this pathway.

What genes are in the Nuclear Receptor transcription pathway pathway?

The Nuclear Receptor transcription pathway pathway involves 42 genes. Key genes include: AR, ESR1, ESR2, ESRRA, ESRRB, ESRRG, HNF4A, HNF4G, NCOR1, NCOR2.

Nuclear Receptor transcription pathway

REACTOME PATHWAY

Reactome: R-HSA-38328042 genes595 compounds

The Nuclear Receptor transcription pathway pathway (Reactome ID: R-HSA-383280) involves 42 genes and is affected by 595 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AR ESR1 ESR2 ESRRA ESRRB ESRRG HNF4A HNF4G NCOR1 NCOR2 NR0B1 NR1D1 NR1D2 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2C1 NR2C2 NR2E1 NR2F1 NR3C1 NR3C2 NR4A1 NR4A2 NR5A1 NR5A2 PGR PPARA+12 more

Compounds Affecting Nuclear Receptor transcription pathway

#	Compound	Targets Hit	Studies
1	Progesterone	—	299
2	Genistein	—	300
3	vinblastine sulfate	—	81
4	Aldosterone	—	300
5	Ethidium	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Triiodothyronine	—	300
8	Spironolactone	—	298
9	Dactinomycin	—	297
10	Clotrimazole	—	296
11	Daunorubicin	—	298
12	chrysin	—	300
13	Troglitazone	—	299
14	Dihydrotestosterone	—	300
15	Ethinyl Estradiol	—	300
16	cycloheximide	—	300
17	Resveratrol	—	298
18	Dasatinib	—	299
19	Retinaldehyde	—	300
20	Gemfibrozil	—	297
21	Azacitidine	—	298
22	Azacitidine	—	300
23	Hexachlorophene	—	300
24	Nisoldipine	—	297
25	Rotenone	—	300
26	Loratadine	—	296
27	Dinitrochlorobenzene	—	300
28	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
29	Emetine	—	298
30	Podophyllotoxin	—	14
31	Simvastatin	—	1,000
32	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
33	Testosterone	—	299
34	Levonorgestrel	—	292
35	Norgestrel	—	300
36	Budesonide	—	1,000
37	Disulfiram	—	297
38	Methylene Blue	—	200
39	Kaempferols	—	300
40	Gestrinone	—	221
41	Promethazine	—	121
42	o-Phthalaldehyde	—	300
43	Vitamin	—	295
44	Idazoxan	—	300
45	Thyroxine	—	994
46	Thyroxine	—	300
47	Medroxyprogesterone Acetate	—	299
48	Flutamide	—	298
49	Testosterone Propionate	—	300
50	Lynestrenol	—	299

About the Nuclear Receptor transcription pathway Pathway

The Nuclear Receptor transcription pathway pathway is catalogued in Reactome (ID: R-HSA-383280) and involves 42 genes. In the BiohacksAI corpus, 595 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AR, ESR1, ESR2, ESRRA, ESRRB.