What compounds affect the VEGFA-VEGFR2 Pathway pathway?

124 compounds in the BiohacksAI corpus have documented interactions with genes in the VEGFA-VEGFR2 Pathway pathway (Reactome ID: R-HSA-4420097). These compounds target 33 genes within this pathway.

What genes are in the VEGFA-VEGFR2 Pathway pathway?

The VEGFA-VEGFR2 Pathway pathway involves 33 genes. Key genes include: AKT3, AXL, CDC42, CYBB, FYN, HSP90AA1, HSPB1, ITGAV, ITGB3, KDR.

VEGFA-VEGFR2 Pathway

REACTOME PATHWAY

Reactome: R-HSA-442009733 genes124 compounds

The VEGFA-VEGFR2 Pathway pathway (Reactome ID: R-HSA-4420097) involves 33 genes and is affected by 124 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 AXL CDC42 CYBB FYN HSP90AA1 HSPB1 ITGAV ITGB3 KDR MAPK11 MAPK12 MAPK13 MAPK14 MAPKAP1 MAPKAPK2 MLST8 MTOR NCF1 NOS3 PDPK1 PIK3CB PIK3R1 PIK3R2 PRKACA PRKACB PRKACG PRKCZ PTK2B RICTOR+3 more

Compounds Affecting VEGFA-VEGFR2 Pathway

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Sorafenib	—	300
3	Dasatinib	—	299
4	Crizotinib	—	298
5	Sirolimus	—	300
6	torin 1	—	10
7	Afatinib	—	297
8	kenpaullone	—	8
9	hydroxyfasudil [Supplementary Concept]	—	11
10	Wortmannin	—	300
11	pictilisib	—	25
12	ly294002	—	11
13	Ku 0063794 [Supplementary Concept]	—	7
14	alpelisib	—	227
15	Anisomycin	—	247
16	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
17	withaferin	—	300
18	alsterpaullone	—	12
19	sp600125	—	117
20	Disulfiram	—	297
21	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	egcg	—	300
24	tyrphostin ag 1478	—	4
25	Sphingosine	—	300
26	Hexachlorophene	—	300
27	Clotrimazole	—	296
28	Ciclopirox	—	88
29	Idazoxan	—	300
30	Masoprocol	—	300
31	triolimus [Supplementary Concept]	—	33
32	monorden	—	8
33	celastrol	—	300
34	Calcimycin	—	216
35	cycloheximide	—	300
36	Idarubicin	—	299
37	Everolimus	—	297
38	Niclosamide	—	299
39	Resveratrol	—	298
40	Axitinib	—	298
41	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
42	Vitamin	—	295
43	Bufotenin	—	93
44	Feprazone	—	63
45	Nocodazole Nocodazole is	—	215
46	Phenoxybenzamine	—	21
47	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
48	Adapalene	—	296
49	alpha-Linolenic Acid	—	300
50	Bortezomib	—	300

About the VEGFA-VEGFR2 Pathway Pathway

The VEGFA-VEGFR2 Pathway pathway is catalogued in Reactome (ID: R-HSA-4420097) and involves 33 genes. In the BiohacksAI corpus, 124 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, AXL, CDC42, CYBB, FYN.