What compounds affect the Interleukin-1 family signaling pathway?

279 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-1 family signaling pathway (Reactome ID: R-HSA-446652). These compounds target 69 genes within this pathway.

What genes are in the Interleukin-1 family signaling pathway?

The Interleukin-1 family signaling pathway involves 69 genes. Key genes include: ADRM1, ALOX5, APP, CASP1, CHUK, CTSG, CUL1, GSDMD, HMGB1, IKBKB.

Interleukin-1 family signaling

REACTOME PATHWAY

Reactome: R-HSA-44665269 genes279 compounds

The Interleukin-1 family signaling pathway (Reactome ID: R-HSA-446652) involves 69 genes and is affected by 279 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ALOX5 APP CASP1 CHUK CTSG CUL1 GSDMD HMGB1 IKBKB IL1B IRAK1 IRAK3 IRAK4 MAP2K1 MAP2K4 MAP3K3 MAP3K7 MAPK8 NFKB1 NFKB2 NFKBIA NOD1 NOD2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6+39 more

Compounds Affecting Interleukin-1 family signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Disulfiram	—	297
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Quercetin	—	300
6	Axitinib	—	298
7	Resveratrol	—	298
8	Crizotinib	—	298
9	Digitoxin	—	300
10	Kaempferols	—	300
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	Hexachlorophene	—	300
13	cycloheximide	—	300
14	Digoxin	—	299
15	Oxyphenbutazone	—	300
16	sp600125	—	117
17	Dasatinib	—	299
18	Anisomycin	—	247
19	Sorafenib	—	300
20	Trifluridine	—	295
21	Astemizole Antihistamine drug now withdrawn from	—	280
22	withaferin	—	300
23	alsterpaullone	—	12
24	cardamonin	—	180
25	Podophyllotoxin	—	14
26	egcg	—	300
27	streptonigrin	—	299
28	chicoric acid	—	117
29	Ethidium	—	300
30	Ethinyl Estradiol	—	300
31	Methylene Blue	—	200
32	Cladribine	—	297
33	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
34	Niclosamide	—	299
35	ninhydrin	—	300
36	Camptothecin	—	300
37	Genistein	—	300
38	Dinitrochlorobenzene	—	300
39	Thioridazine	—	35
40	vinblastine sulfate	—	81
41	chrysin	—	300
42	celastrol	—	300
43	Harmaline	—	300
44	Nisoldipine	—	297
45	Perphenazine	—	297
46	triflupromazine hydrochloride	—	12
47	Chlorhexidine	—	299
48	Celecoxib	—	295
49	Masoprocol	—	300
50	Rutin	—	300

About the Interleukin-1 family signaling Pathway

The Interleukin-1 family signaling pathway is catalogued in Reactome (ID: R-HSA-446652) and involves 69 genes. In the BiohacksAI corpus, 279 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ALOX5, APP, CASP1, CHUK.