What compounds affect the MAP kinase activation pathway?

181 compounds in the BiohacksAI corpus have documented interactions with genes in the MAP kinase activation pathway (Reactome ID: R-HSA-450294). These compounds target 31 genes within this pathway.

What genes are in the MAP kinase activation pathway?

The MAP kinase activation pathway involves 31 genes. Key genes include: CHUK, CREB1, CUL1, DUSP3, FOS, IKBKB, IRAK1, JUN, MAP2K1, MAP2K3.

MAP kinase activation

REACTOME PATHWAY

Reactome: R-HSA-45029431 genes181 compounds

The MAP kinase activation pathway (Reactome ID: R-HSA-450294) involves 31 genes and is affected by 181 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CHUK CREB1 CUL1 DUSP3 FOS IKBKB IRAK1 JUN MAP2K1 MAP2K3 MAP2K4 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 NFKB1 NOD1 NOD2 PPP2CA RIPK2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5+1 more

Compounds Affecting MAP kinase activation

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	sp600125	—	117
3	Afatinib	—	297
4	Anisomycin	—	247
5	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
6	fisetin	—	78
7	Crizotinib	—	298
8	Dasatinib	—	299
9	withaferin	—	300
10	Axitinib	—	298
11	Disulfiram	—	297
12	Oxyphenbutazone	—	300
13	Quercetin	—	300
14	alsterpaullone	—	12
15	pictilisib	—	25
16	egcg	—	300
17	Masoprocol	—	300
18	cycloheximide	—	300
19	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
20	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
21	tyrphostin ag 1478	—	4
22	pd98059	—	7
23	trametinib	—	296
24	cardamonin	—	180
25	Vemurafenib	—	298
26	hydroxyfasudil [Supplementary Concept]	—	11
27	DEAD-box RNA Helicases	—	169
28	Thioctic Acid	—	298
29	Diphenhydramine	—	14
30	glaucarubinone	—	10
31	Thioctic Acid	—	300
32	Lithocholic Acid	—	300
33	Lovastatin	—	300
34	Podophyllotoxin	—	14
35	Promethazine	—	121
36	Sertraline	—	1,000
37	Clotrimazole	—	296
38	ninhydrin	—	300
39	Nisoldipine	—	297
40	Nocodazole Nocodazole is	—	215
41	Norepinephrine Precursor of epinephrine that is secreted by	—	298
42	Salmeterol Xinafoate	—	227
43	Thioridazine	—	35
44	Bortezomib	—	300
45	trequinsin hydrochloride	—	1
46	Genistein	—	300
47	Resveratrol	—	298
48	Kaempferols	—	300
49	daph	—	2
50	Hexachlorophene	—	300

About the MAP kinase activation Pathway

The MAP kinase activation pathway is catalogued in Reactome (ID: R-HSA-450294) and involves 31 genes. In the BiohacksAI corpus, 181 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHUK, CREB1, CUL1, DUSP3, FOS.