What compounds affect the C-type lectin receptors (CLRs) pathway?

278 compounds in the BiohacksAI corpus have documented interactions with genes in the C-type lectin receptors (CLRs) pathway (Reactome ID: R-HSA-5621481). These compounds target 57 genes within this pathway.

What genes are in the C-type lectin receptors (CLRs) pathway?

The C-type lectin receptors (CLRs) pathway involves 57 genes. Key genes include: ADRM1, CHUK, CREBBP, CUL1, EP300, FYN, IKBKB, IL1B, LYN, MAP3K7.

C-type lectin receptors (CLRs)

REACTOME PATHWAY

Reactome: R-HSA-562148157 genes278 compounds

The C-type lectin receptors (CLRs) pathway (Reactome ID: R-HSA-5621481) involves 57 genes and is affected by 278 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CHUK CREBBP CUL1 EP300 FYN IKBKB IL1B LYN MAP3K7 MUC1 NFKB1 NFKB2 NFKBIA PDPK1 PRKACA PRKACB PRKACG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5+27 more

Compounds Affecting C-type lectin receptors (CLRs)

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	sp600125	—	117
4	Crizotinib	—	298
5	Sorafenib	—	300
6	Quercetin	—	300
7	alsterpaullone	—	12
8	kenpaullone	—	8
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	Dasatinib	—	299
11	tyrphostin ag 1478	—	4
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	Resveratrol	—	298
14	Disulfiram	—	297
15	Podophyllotoxin	—	14
16	withaferin	—	300
17	Kaempferols	—	300
18	egcg	—	300
19	chicoric acid	—	117
20	hydroxyfasudil [Supplementary Concept]	—	11
21	Chlorhexidine	—	299
22	Niclosamide	—	299
23	Trifluridine	—	295
24	Astemizole Antihistamine drug now withdrawn from	—	280
25	Rutin	—	300
26	Withania	—	500
27	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
28	tamarixetin	—	26
29	Colchicine	—	300
30	cycloheximide	—	300
31	Digoxin	—	299
32	Lovastatin	—	300
33	Mometasone Furoate	—	292
34	piceatannol	—	300
35	alpelisib	—	227
36	Nocodazole Nocodazole is	—	215
37	Sertraline	—	1,000
38	Ursolic Acid	—	300
39	Afatinib	—	297
40	Beclomethasone	—	300
41	Cerulenin	—	300
42	Digitoxin	—	300
43	Hexachlorophene	—	300
44	lidoflazine	—	278
45	ly294002	—	11
46	monorden	—	8
47	Nisoldipine	—	297
48	Papaverine	—	299
49	Perphenazine	—	297
50	Vemurafenib	—	298

About the C-type lectin receptors (CLRs) Pathway

The C-type lectin receptors (CLRs) pathway is catalogued in Reactome (ID: R-HSA-5621481) and involves 57 genes. In the BiohacksAI corpus, 278 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CHUK, CREBBP, CUL1, EP300.