What compounds affect the FLT3 Signaling pathway?

215 compounds in the BiohacksAI corpus have documented interactions with genes in the FLT3 Signaling pathway (Reactome ID: R-HSA-9607240). These compounds target 13 genes within this pathway.

What genes are in the FLT3 Signaling pathway?

The FLT3 Signaling pathway involves 13 genes. Key genes include: ABL2, AKT3, BCL2L11, CSK, FLT3, FOXO3, FYN, GRB2, HCK, LCK.

FLT3 Signaling

REACTOME PATHWAY

Reactome: R-HSA-960724013 genes215 compounds

The FLT3 Signaling pathway (Reactome ID: R-HSA-9607240) involves 13 genes and is affected by 215 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL2 AKT3 BCL2L11 CSK FLT3 FOXO3 FYN GRB2 HCK LCK PIK3R1 STAT5A SYK

Compounds Affecting FLT3 Signaling

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	tyrphostin ag 1478	—	4
4	Crizotinib	—	298
5	Axitinib	—	298
6	Afatinib	—	297
7	kenpaullone	—	8
8	sp600125	—	117
9	ly294002	—	11
10	pictilisib	—	25
11	Quercetin	—	300
12	piceatannol	—	300
13	torin 1	—	10
14	alpelisib	—	227
15	Kaempferols	—	300
16	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
17	Acetic Acid Product of	—	300
18	Ouabain	—	300
19	Atorvastatin	—	1,000
20	Simvastatin	—	1,000
21	Methotrexate	—	289
22	Chlorhexidine	—	299
23	Clofarabine	—	298
24	Colchicine	—	300
25	cycloheximide	—	300
26	deguelin [Supplementary Concept]	—	151
27	Digoxin	—	299
28	Disulfiram	—	297
29	Emetine	—	298
30	Ezetimibe	—	296
31	Lovastatin	—	300
32	Medroxyprogesterone Acetate	—	299
33	Melphalan	—	300
34	Mometasone Furoate	—	292
35	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
36	Niclosamide	—	299
37	Podophyllotoxin	—	14
38	Thapsigargin	—	300
39	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
40	Trifluridine	—	295
41	fisetin	—	78
42	ag490	—	14
43	Azathioprine	—	300
44	Bortezomib	—	300
45	Maprotiline	—	299
46	Nocodazole Nocodazole is	—	215
47	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
48	Tripterygium	—	300
49	Vincristine	—	299
50	withaferin	—	300

About the FLT3 Signaling Pathway

The FLT3 Signaling pathway is catalogued in Reactome (ID: R-HSA-9607240) and involves 13 genes. In the BiohacksAI corpus, 215 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL2, AKT3, BCL2L11, CSK, FLT3.