What genes are in the Signaling by Rho GTPases, Miro GTPases and RHOBTB3 pathway?

The Signaling by Rho GTPases, Miro GTPases and RHOBTB3 pathway involves 95 genes. Key genes include: ABL1, ABL2, AR, ARHGAP35, AURKB, BCR, BIRC5, BTK, BUB1B-PAK6, CCDC88A.

Signaling by Rho GTPases, Miro GTPases and RHOBTB3

Q: What compounds affect the Signaling by Rho GTPases, Miro GTPases and RHOBTB3 pathway?

441 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by Rho GTPases, Miro GTPases and RHOBTB3 pathway (Reactome ID: R-HSA-9716542). These compounds target 95 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-971654295 genes441 compounds

The Signaling by Rho GTPases, Miro GTPases and RHOBTB3 pathway (Reactome ID: R-HSA-9716542) involves 95 genes and is affected by 441 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ABL2 AR ARHGAP35 AURKB BCR BIRC5 BTK BUB1B-PAK6 CCDC88A CCT2 CDC37 CDC42 CDC42BPA CDC42BPB CFL1 CFTR CIT CSK CYBB EPHA2 GRB2 HSP90AA1 HSP90AB1 HSPE1 HTR7 KDM1A KDM4C LCK LIMK1+65 more

Compounds Affecting Signaling by Rho GTPases, Miro GTPases and RHOBTB3

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	Nocodazole Nocodazole is	—	215
4	Colchicine	—	300
5	Crizotinib	—	298
6	vinblastine sulfate	—	81
7	Podophyllotoxin	—	14
8	Vincristine	—	299
9	kenpaullone	—	8
10	Demecolcine	—	246
11	Vorinostat	—	299
12	Noscapine	—	300
13	Maytansine	—	300
14	Quercetin	—	300
15	alsterpaullone	—	12
16	Axitinib	—	298
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	sp600125	—	117
19	Afatinib	—	297
20	tyrphostin ag 1478	—	4
21	hydroxyfasudil [Supplementary Concept]	—	11
22	Hexachlorophene	—	300
23	triolimus [Supplementary Concept]	—	33
24	celastrol	—	300
25	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
26	Clotrimazole	—	296
27	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
28	Wortmannin	—	300
29	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
30	cycloheximide	—	300
31	Disulfiram	—	297
32	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
33	Methylene Blue	—	200
34	Masoprocol	—	300
35	Genistein	—	300
36	egcg	—	300
37	Niclosamide	—	299
38	Idarubicin	—	299
39	plumbagin [Supplementary Concept]	—	300
40	withaferin	—	300
41	Hydrocortisone	—	299
42	Hydrocortisone	—	298
43	Nisoldipine	—	297
44	Kaempferols	—	300
45	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
46	Vitamin K 3	—	300
47	Oxyphenbutazone	—	300
48	Imatinib Mesylate	—	300
49	rafoxanide	—	172
50	caffeic acid	—	300

About the Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Pathway

The Signaling by Rho GTPases, Miro GTPases and RHOBTB3 pathway is catalogued in Reactome (ID: R-HSA-9716542) and involves 95 genes. In the BiohacksAI corpus, 441 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ABL2, AR, ARHGAP35, AURKB.