What compounds affect the Toll Like Receptor 4 (TLR4) Cascade pathway?

281 compounds in the BiohacksAI corpus have documented interactions with genes in the Toll Like Receptor 4 (TLR4) Cascade pathway (Reactome ID: R-HSA-166016). These compounds target 48 genes within this pathway.

What genes are in the Toll Like Receptor 4 (TLR4) Cascade pathway?

The Toll Like Receptor 4 (TLR4) Cascade pathway involves 48 genes. Key genes include: APP, BTK, CHUK, CREB1, CUL1, DUSP3, FOS, HMGB1, IKBKB, IKBKE.

Toll Like Receptor 4 (TLR4) Cascade

REACTOME PATHWAY

Reactome: R-HSA-16601648 genes281 compounds

The Toll Like Receptor 4 (TLR4) Cascade pathway (Reactome ID: R-HSA-166016) involves 48 genes and is affected by 281 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP BTK CHUK CREB1 CUL1 DUSP3 FOS HMGB1 IKBKB IKBKE IRAK1 IRAK3 IRAK4 ITGB2 JUN MAP2K1 MAP2K3 MAP2K4 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 NFKB1+18 more

Compounds Affecting Toll Like Receptor 4 (TLR4) Cascade

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Crizotinib	—	298
3	sp600125	—	117
4	Quercetin	—	300
5	Dasatinib	—	299
6	withaferin	—	300
7	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Disulfiram	—	297
10	Axitinib	—	298
11	Afatinib	—	297
12	Anisomycin	—	247
13	Resveratrol	—	298
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	fisetin	—	78
16	Bortezomib	—	300
17	Oxyphenbutazone	—	300
18	Kaempferols	—	300
19	pictilisib	—	25
20	Trifluridine	—	295
21	plumbagin [Supplementary Concept]	—	300
22	cycloheximide	—	300
23	Digitoxin	—	300
24	Digoxin	—	299
25	pd98059	—	7
26	egcg	—	300
27	Podophyllotoxin	—	14
28	tyrphostin ag 1478	—	4
29	alsterpaullone	—	12
30	chicoric acid	—	117
31	Vemurafenib	—	298
32	Hexachlorophene	—	300
33	Methylene Blue	—	200
34	Cladribine	—	297
35	ninhydrin	—	300
36	Camptothecin	—	300
37	Genistein	—	300
38	daph	—	2
39	Clotrimazole	—	296
40	Thioridazine	—	35
41	vinblastine sulfate	—	81
42	Nisoldipine	—	297
43	Nocodazole Nocodazole is	—	215
44	Sertraline	—	1,000
45	Adenosine Triphosphate	—	300
46	Salmeterol Xinafoate	—	227
47	Lovastatin	—	300
48	Masoprocol	—	300
49	Rutin	—	300
50	Withania	—	500

About the Toll Like Receptor 4 (TLR4) Cascade Pathway

The Toll Like Receptor 4 (TLR4) Cascade pathway is catalogued in Reactome (ID: R-HSA-166016) and involves 48 genes. In the BiohacksAI corpus, 281 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, BTK, CHUK, CREB1, CUL1.