What compounds affect the Toll Like Receptor TLR1:TLR2 Cascade pathway?

280 compounds in the BiohacksAI corpus have documented interactions with genes in the Toll Like Receptor TLR1:TLR2 Cascade pathway (Reactome ID: R-HSA-168179). These compounds target 43 genes within this pathway.

What genes are in the Toll Like Receptor TLR1:TLR2 Cascade pathway?

The Toll Like Receptor TLR1:TLR2 Cascade pathway involves 43 genes. Key genes include: APP, BTK, CHUK, CREB1, CUL1, DUSP3, FOS, HMGB1, IKBKB, IRAK1.

Toll Like Receptor TLR1:TLR2 Cascade

REACTOME PATHWAY

Reactome: R-HSA-16817943 genes280 compounds

The Toll Like Receptor TLR1:TLR2 Cascade pathway (Reactome ID: R-HSA-168179) involves 43 genes and is affected by 280 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP BTK CHUK CREB1 CUL1 DUSP3 FOS HMGB1 IKBKB IRAK1 IRAK3 IRAK4 JUN MAP2K1 MAP2K3 MAP2K4 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 NFKB1 NFKB2 NFKBIA+13 more

Compounds Affecting Toll Like Receptor TLR1:TLR2 Cascade

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	sp600125	—	117
3	Crizotinib	—	298
4	Quercetin	—	300
5	Dasatinib	—	299
6	withaferin	—	300
7	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Afatinib	—	297
10	Anisomycin	—	247
11	Disulfiram	—	297
12	Axitinib	—	298
13	Resveratrol	—	298
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	fisetin	—	78
16	Bortezomib	—	300
17	Oxyphenbutazone	—	300
18	Kaempferols	—	300
19	pictilisib	—	25
20	Trifluridine	—	295
21	plumbagin [Supplementary Concept]	—	300
22	cycloheximide	—	300
23	Digitoxin	—	300
24	Digoxin	—	299
25	pd98059	—	7
26	egcg	—	300
27	Podophyllotoxin	—	14
28	tyrphostin ag 1478	—	4
29	alsterpaullone	—	12
30	chicoric acid	—	117
31	Hexachlorophene	—	300
32	Methylene Blue	—	200
33	Cladribine	—	297
34	ninhydrin	—	300
35	Camptothecin	—	300
36	Genistein	—	300
37	daph	—	2
38	Clotrimazole	—	296
39	Thioridazine	—	35
40	vinblastine sulfate	—	81
41	Nisoldipine	—	297
42	Nocodazole Nocodazole is	—	215
43	Sertraline	—	1,000
44	Adenosine Triphosphate	—	300
45	Salmeterol Xinafoate	—	227
46	Masoprocol	—	300
47	Rutin	—	300
48	Withania	—	500
49	tamarixetin	—	26
50	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300

About the Toll Like Receptor TLR1:TLR2 Cascade Pathway

The Toll Like Receptor TLR1:TLR2 Cascade pathway is catalogued in Reactome (ID: R-HSA-168179) and involves 43 genes. In the BiohacksAI corpus, 280 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, BTK, CHUK, CREB1, CUL1.