What compounds affect the RHO GTPase Effectors pathway?

377 compounds in the BiohacksAI corpus have documented interactions with genes in the RHO GTPase Effectors pathway (Reactome ID: R-HSA-195258). These compounds target 58 genes within this pathway.

What genes are in the RHO GTPase Effectors pathway?

The RHO GTPase Effectors pathway involves 58 genes. Key genes include: ABL1, AR, AURKB, BIRC5, BTK, CDC42, CFL1, CFTR, CIT, CYBB.

RHO GTPase Effectors

REACTOME PATHWAY

Reactome: R-HSA-19525858 genes377 compounds

The RHO GTPase Effectors pathway (Reactome ID: R-HSA-195258) involves 58 genes and is affected by 377 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 AR AURKB BIRC5 BTK CDC42 CFL1 CFTR CIT CYBB GRB2 KDM1A KDM4C LIMK1 LIMK2 MAPK1 MAPK11 MAPK14 MAPK3 MEN1 MYLK NCF1 NOX1 PDPK1 PIK3C3 PIN1 PKN1 PKN2 PKN3 PLK1+28 more

Compounds Affecting RHO GTPase Effectors

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	vinblastine sulfate	—	81
4	Podophyllotoxin	—	14
5	Vincristine	—	299
6	Demecolcine	—	246
7	Vorinostat	—	299
8	Noscapine	—	300
9	Maytansine	—	300
10	Dasatinib	—	299
11	Sorafenib	—	300
12	Quercetin	—	300
13	kenpaullone	—	8
14	alsterpaullone	—	12
15	Crizotinib	—	298
16	hydroxyfasudil [Supplementary Concept]	—	11
17	sp600125	—	117
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	tyrphostin ag 1478	—	4
20	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
21	Afatinib	—	297
22	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
23	withaferin	—	300
24	Disulfiram	—	297
25	Hexachlorophene	—	300
26	Nisoldipine	—	297
27	Clotrimazole	—	296
28	Methylene Blue	—	200
29	Genistein	—	300
30	triolimus [Supplementary Concept]	—	33
31	Vitamin K 3	—	300
32	Oxyphenbutazone	—	300
33	Niclosamide	—	299
34	celastrol	—	300
35	Anisomycin	—	247
36	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
37	plumbagin [Supplementary Concept]	—	300
38	fisetin	—	78
39	Axitinib	—	298
40	Wortmannin	—	300
41	Okadaic Acid	—	300
42	Progesterone	—	299
43	Medroxyprogesterone Acetate	—	299
44	Prednisolone	—	1,000
45	Budesonide	—	1,000
46	cycloheximide	—	300
47	Ethidium	—	300
48	Hydrocortisone	—	299
49	Betamethasone	—	299
50	Dactinomycin	—	297

About the RHO GTPase Effectors Pathway

The RHO GTPase Effectors pathway is catalogued in Reactome (ID: R-HSA-195258) and involves 58 genes. In the BiohacksAI corpus, 377 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, AR, AURKB, BIRC5, BTK.