What genes are in the SUMO E3 ligases SUMOylate target proteins pathway?

The SUMO E3 ligases SUMOylate target proteins pathway involves 54 genes. Key genes include: AR, AURKA, AURKB, BIRC5, BLM, BRCA1, CREBBP, CTBP1, DNMT1, DNMT3B.

SUMO E3 ligases SUMOylate target proteins

Q: What compounds affect the SUMO E3 ligases SUMOylate target proteins pathway?

643 compounds in the BiohacksAI corpus have documented interactions with genes in the SUMO E3 ligases SUMOylate target proteins pathway (Reactome ID: R-HSA-3108232). These compounds target 54 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-310823254 genes643 compounds

The SUMO E3 ligases SUMOylate target proteins pathway (Reactome ID: R-HSA-3108232) involves 54 genes and is affected by 643 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AR AURKA AURKB BIRC5 BLM BRCA1 CREBBP CTBP1 DNMT1 DNMT3B EIF2AK2 EP300 ESR1 HDAC1 HDAC2 HDAC4 HDAC7 HIPK2 IKBKE MDM2 MITF NCOA1 NCOR2 NFKB2 NFKBIA NPM1 NR1H2 NR1H3 NR1H4 NR1I2+24 more

Compounds Affecting SUMO E3 ligases SUMOylate target proteins

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	Ethidium	—	300
3	vinblastine sulfate	—	81
4	Progesterone	—	299
5	cycloheximide	—	300
6	Azacitidine	—	298
7	Azacitidine	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Methylene Blue	—	200
10	Quercetin	—	300
11	Podophyllotoxin	—	14
12	Resveratrol	—	298
13	Bortezomib	—	300
14	Triiodothyronine	—	300
15	Spironolactone	—	298
16	Hexachlorophene	—	300
17	Genistein	—	300
18	Nocodazole Nocodazole is	—	215
19	Dactinomycin	—	297
20	Digoxin	—	299
21	Kaempferols	—	300
22	Dinitrochlorobenzene	—	300
23	Celecoxib	—	295
24	Colchicine	—	300
25	chrysin	—	300
26	Niclosamide	—	299
27	Troglitazone	—	299
28	Aldosterone	—	300
29	Vorinostat	—	299
30	Methotrexate	—	289
31	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
32	Dihydrotestosterone	—	300
33	Chlorhexidine	—	299
34	Nisoldipine	—	297
35	Clotrimazole	—	296
36	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
37	Astemizole Antihistamine drug now withdrawn from	—	280
38	Dasatinib	—	299
39	Emetine	—	298
40	Vincristine	—	299
41	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
42	Camptothecin	—	300
43	Ethinyl Estradiol	—	300
44	Disulfiram	—	297
45	Rotenone	—	300
46	Loratadine	—	296
47	Ciclopirox	—	88
48	Melphalan	—	300
49	o-Phthalaldehyde	—	300
50	Retinaldehyde	—	300

About the SUMO E3 ligases SUMOylate target proteins Pathway

The SUMO E3 ligases SUMOylate target proteins pathway is catalogued in Reactome (ID: R-HSA-3108232) and involves 54 genes. In the BiohacksAI corpus, 643 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AR, AURKA, AURKB, BIRC5, BLM.