What genes are in the Regulation of T cell activation by CD28 family pathway?

The Regulation of T cell activation by CD28 family pathway involves 99 genes. Key genes include: ADRM1, AGO2, AKT3, ASH2L, BRD4, CDC42, CDK4, COPS5, CREBBP, CSK.

Regulation of T cell activation by CD28 family

Q: What compounds affect the Regulation of T cell activation by CD28 family pathway?

358 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of T cell activation by CD28 family pathway (Reactome ID: R-HSA-388841). These compounds target 99 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-38884199 genes358 compounds

The Regulation of T cell activation by CD28 family pathway (Reactome ID: R-HSA-388841) involves 99 genes and is affected by 358 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 AKT3 ASH2L BRD4 CDC42 CDK4 COPS5 CREBBP CSK CSNK2A1 CSNK2A2 CSNK2B CUL1 DPY30 EED EP300 EPAS1 EZH2 FOS FYN GRB2 GSK3B HIF1A JUN KMT2A LCK LYN MAPKAP1 MLST8+69 more

Compounds Affecting Regulation of T cell activation by CD28 family

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Quercetin	—	300
3	ly294002	—	11
4	Reserpine	—	297
5	Niclosamide	—	299
6	Rotenone	—	300
7	Kaempferols	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Oleanolic Acid	—	300
11	egcg	—	300
12	Ursolic Acid	—	300
13	Antimycin	—	300
14	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
15	Sirolimus	—	300
16	pictilisib	—	25
17	Sorafenib	—	300
18	Resveratrol	—	298
19	sp600125	—	117
20	Berberine	—	300
21	Adenosine Monophosphate Adenine nucleotide containing	—	300
22	chrysin	—	300
23	torin 1	—	10
24	Wortmannin	—	300
25	kenpaullone	—	8
26	Proguanil	—	299
27	Metformin	—	1,000
28	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
29	tyrphostin ag 1478	—	4
30	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
31	Dasatinib	—	299
32	Crizotinib	—	298
33	s adenosylhomocysteine	—	300
34	Podophyllotoxin	—	14
35	Axitinib	—	298
36	Disulfiram	—	297
37	Rutin	—	300
38	Ku 0063794 [Supplementary Concept]	—	7
39	alpelisib	—	227
40	alsterpaullone	—	12
41	Colchicine	—	300
42	Genistein	—	300
43	Hexachlorophene	—	300
44	Nocodazole Nocodazole is	—	215
45	ninhydrin	—	300
46	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
47	Clotrimazole	—	296
48	Masoprocol	—	300
49	Emetine	—	298
50	fisetin	—	78

About the Regulation of T cell activation by CD28 family Pathway

The Regulation of T cell activation by CD28 family pathway is catalogued in Reactome (ID: R-HSA-388841) and involves 99 genes. In the BiohacksAI corpus, 358 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, AKT3, ASH2L, BRD4.