What compounds affect the MAPK1/MAPK3 signaling pathway?

134 compounds in the BiohacksAI corpus have documented interactions with genes in the MAPK1/MAPK3 signaling pathway (Reactome ID: R-HSA-5684996). These compounds target 92 genes within this pathway.

What genes are in the MAPK1/MAPK3 signaling pathway?

The MAPK1/MAPK3 signaling pathway involves 92 genes. Key genes include: ADRM1, ARAF, ARRB1, BCL2L1, BRAF, CAMK2B, CAMK2D, CDK1, CHURC1-FNTB, CSK.

MAPK1/MAPK3 signaling

REACTOME PATHWAY

Reactome: R-HSA-568499692 genes134 compounds

The MAPK1/MAPK3 signaling pathway (Reactome ID: R-HSA-5684996) involves 92 genes and is affected by 134 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ARAF ARRB1 BCL2L1 BRAF CAMK2B CAMK2D CDK1 CHURC1-FNTB CSK DUSP5 EGFR ERBB2 ERBB3 ERBB4 FGF22 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FNTA FNTB FYN GRB2 GRIN1 GRIN2B ICMT IL3 IL6+62 more

Compounds Affecting MAPK1/MAPK3 signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Sorafenib	—	300
3	Dasatinib	—	299
4	sp600125	—	117
5	Axitinib	—	298
6	Reserpine	—	297
7	Crizotinib	—	298
8	Quercetin	—	300
9	Afatinib	—	297
10	tyrphostin ag 1478	—	4
11	alsterpaullone	—	12
12	kenpaullone	—	8
13	pd98059	—	7
14	pictilisib	—	25
15	Vemurafenib	—	298
16	trametinib	—	296
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
19	withaferin	—	300
20	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
21	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
22	tyrphostin ag 1295	—	1
23	egcg	—	300
24	ly294002	—	11
25	Sirolimus	—	300
26	Gliotoxin	—	300
27	Lovastatin	—	300
28	Okadaic Acid	—	300
29	plumbagin [Supplementary Concept]	—	300
30	Clotrimazole	—	296
31	fisetin	—	78
32	Glutamic Acid	—	297
33	Glutamic Acid	—	300
34	Glycine	—	300
35	pentamidine	—	299
36	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
37	Dextrorphan Dextro form of levorphanol. It acts as	—	300
38	Levorphanol	—	297
39	cycloserine	—	298
40	Aspartic Acid	—	300
41	eliprodil	—	33
42	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
43	D-Aspartic Acid	—	29
44	Ethidium	—	300
45	Dextrothyroxine	—	134
46	Dizocilpine Maleate	—	300
47	Ibotenic Acid	—	300
48	Spermine	—	300
49	chrysin	—	300
50	Genistein	—	300

About the MAPK1/MAPK3 signaling Pathway

The MAPK1/MAPK3 signaling pathway is catalogued in Reactome (ID: R-HSA-5684996) and involves 92 genes. In the BiohacksAI corpus, 134 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ARAF, ARRB1, BCL2L1, BRAF.