What genes are in the Intracellular signaling by second messengers pathway?

The Intracellular signaling by second messengers pathway involves 122 genes. Key genes include: ADCY9, ADRM1, AGO2, AKT3, BAD, CAMK2B, CAMK2D, CAMKK1, CAMKK2, CASP9.

Intracellular signaling by second messengers

Q: What compounds affect the Intracellular signaling by second messengers pathway?

488 compounds in the BiohacksAI corpus have documented interactions with genes in the Intracellular signaling by second messengers pathway (Reactome ID: R-HSA-9006925). These compounds target 122 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-9006925122 genes488 compounds

The Intracellular signaling by second messengers pathway (Reactome ID: R-HSA-9006925) involves 122 genes and is affected by 488 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 ADRM1 AGO2 AKT3 BAD CAMK2B CAMK2D CAMKK1 CAMKK2 CASP9 CHUK CREB1 CSNK2A1 CSNK2A2 CSNK2B EED EGFR ERBB2 ERBB3 ERBB4 ESR1 ESR2 EZH2 FGF22 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FOXO3+92 more

Compounds Affecting Intracellular signaling by second messengers

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	sp600125	—	117
3	Sorafenib	—	300
4	Quercetin	—	300
5	Dasatinib	—	299
6	Reserpine	—	297
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Axitinib	—	298
9	pictilisib	—	25
10	Crizotinib	—	298
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	ly294002	—	11
14	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
15	chrysin	—	300
16	Kaempferols	—	300
17	Daunorubicin	—	298
18	Sirolimus	—	300
19	alsterpaullone	—	12
20	kenpaullone	—	8
21	Afatinib	—	297
22	Disulfiram	—	297
23	Resveratrol	—	298
24	Vorinostat	—	299
25	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
26	Ursolic Acid	—	300
27	torin 1	—	10
28	tyrphostin ag 1478	—	4
29	Genistein	—	300
30	Methylene Blue	—	200
31	Camptothecin	—	300
32	Ku 0063794 [Supplementary Concept]	—	7
33	egcg	—	300
34	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
35	Dactinomycin	—	297
36	Rotenone	—	300
37	vinblastine sulfate	—	81
38	Celecoxib	—	295
39	Clotrimazole	—	296
40	Nisoldipine	—	297
41	Astemizole Antihistamine drug now withdrawn from	—	280
42	Wortmannin	—	300
43	alpelisib	—	227
44	fisetin	—	78
45	Ethidium	—	300
46	cycloheximide	—	300
47	Hexachlorophene	—	300
48	Niclosamide	—	299
49	Loratadine	—	296
50	Masoprocol	—	300

About the Intracellular signaling by second messengers Pathway

The Intracellular signaling by second messengers pathway is catalogued in Reactome (ID: R-HSA-9006925) and involves 122 genes. In the BiohacksAI corpus, 488 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, ADRM1, AGO2, AKT3, BAD.