What genes are in the Constitutive Signaling by Aberrant PI3K in Cancer pathway?

The Constitutive Signaling by Aberrant PI3K in Cancer pathway involves 29 genes. Key genes include: EGFR, ERBB2, ERBB3, ERBB4, ESR1, ESR2, FGF22, FGFR1, FGFR2, FGFR3.

Constitutive Signaling by Aberrant PI3K in Cancer

Q: What compounds affect the Constitutive Signaling by Aberrant PI3K in Cancer pathway?

315 compounds in the BiohacksAI corpus have documented interactions with genes in the Constitutive Signaling by Aberrant PI3K in Cancer pathway (Reactome ID: R-HSA-2219530). These compounds target 29 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-221953029 genes315 compounds

The Constitutive Signaling by Aberrant PI3K in Cancer pathway (Reactome ID: R-HSA-2219530) involves 29 genes and is affected by 315 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EGFR ERBB2 ERBB3 ERBB4 ESR1 ESR2 FGF22 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FYN GRB2 KIT LCK MET NTRK2 NTRK3 PDGFRA PDGFRB PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 SRC

Compounds Affecting Constitutive Signaling by Aberrant PI3K in Cancer

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Sorafenib	—	300
3	Axitinib	—	298
4	Crizotinib	—	298
5	sp600125	—	117
6	Afatinib	—	297
7	pictilisib	—	25
8	tyrphostin ag 1478	—	4
9	Sirolimus	—	300
10	Quercetin	—	300
11	ly294002	—	11
12	Wortmannin	—	300
13	Resveratrol	—	298
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	kenpaullone	—	8
16	alpelisib	—	227
17	Genistein	—	300
18	Kaempferols	—	300
19	Dactinomycin	—	297
20	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
21	tyrphostin ag 1295	—	1
22	torin 1	—	10
23	Levonorgestrel	—	292
24	Norgestrel	—	300
25	Ethinyl Estradiol	—	300
26	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
27	Methyltestosterone	—	300
28	Dehydroepiandrosterone	—	300
29	Dehydroepiandrosterone	—	300
30	Fulvestrant	—	295
31	Danazol	—	298
32	Estrone	—	300
33	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
34	Rotenone	—	300
35	Dihydrotestosterone	—	300
36	Ethidium	—	300
37	Ethynodiol Diacetate	—	300
38	Flutamide	—	298
39	Estriol	—	300
40	Mestranol	—	300
41	Norethindrone	—	300
42	Oxymetholone	—	298
43	Testosterone Propionate	—	300
44	Gestrinone	—	221
45	Hexachlorophene	—	300
46	Lynestrenol	—	299
47	Pueraria	—	300
48	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
49	Progesterone	—	299
50	Vitamin	—	295

About the Constitutive Signaling by Aberrant PI3K in Cancer Pathway

The Constitutive Signaling by Aberrant PI3K in Cancer pathway is catalogued in Reactome (ID: R-HSA-2219530) and involves 29 genes. In the BiohacksAI corpus, 315 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EGFR, ERBB2, ERBB3, ERBB4, ESR1.