What compounds affect the Vesicle-mediated transport pathway?

329 compounds in the BiohacksAI corpus have documented interactions with genes in the Vesicle-mediated transport pathway (Reactome ID: R-HSA-5653656). These compounds target 74 genes within this pathway.

What genes are in the Vesicle-mediated transport pathway?

The Vesicle-mediated transport pathway involves 74 genes. Key genes include: AAK1, ADRB2, AGTR1, AKT3, ALB, APP, ARRB1, AVPR2, CFTR, CHRM2.

Vesicle-mediated transport

REACTOME PATHWAY

Reactome: R-HSA-565365674 genes329 compounds

The Vesicle-mediated transport pathway (Reactome ID: R-HSA-5653656) involves 74 genes and is affected by 329 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AAK1 ADRB2 AGTR1 AKT3 ALB APP ARRB1 AVPR2 CFTR CHRM2 COPS5 CSNK1D CYTH2 EGFR F5 FOLR1 GAK GALNT1 GALNT2 GJB2 GRB2 GRIA1 GRK2 HBA1 HBA2 HBB HMGB1 HSP90AA1 HSP90B1 HSPA8+44 more

Compounds Affecting Vesicle-mediated transport

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Podophyllotoxin	—	14
4	Noscapine	—	300
5	Vorinostat	—	299
6	vinblastine sulfate	—	81
7	Vincristine	—	299
8	Demecolcine	—	246
9	Maytansine	—	300
10	Niclosamide	—	299
11	Adenosine Monophosphate Adenine nucleotide containing	—	300
12	Quercetin	—	300
13	Disulfiram	—	297
14	Proguanil	—	299
15	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
16	Berberine	—	300
17	Ursolic Acid	—	300
18	Antimycin	—	300
19	Oleanolic Acid	—	300
20	Rotenone	—	300
21	Metformin	—	1,000
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	Aripiprazole	—	298
24	Hexachlorophene	—	300
25	Clotrimazole	—	296
26	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
27	Kaempferols	—	300
28	pictilisib	—	25
29	Chlorhexidine	—	299
30	Nadolol	—	297
31	Carvedilol	—	296
32	Astemizole Antihistamine drug now withdrawn from	—	280
33	Masoprocol	—	300
34	Amoxapine	—	259
35	kenpaullone	—	8
36	Ethidium	—	300
37	Methylene Blue	—	200
38	alsterpaullone	—	12
39	Digoxin	—	299
40	Axitinib	—	298
41	candesartan cilexetil [Supplementary Concept]	—	300
42	caffeic acid	—	300
43	Catechin	—	300
44	Dasatinib	—	299
45	Afatinib	—	297
46	Crizotinib	—	298
47	Oxytetracycline	—	300
48	sp600125	—	117
49	diallyl trisulfide	—	246
50	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300

About the Vesicle-mediated transport Pathway

The Vesicle-mediated transport pathway is catalogued in Reactome (ID: R-HSA-5653656) and involves 74 genes. In the BiohacksAI corpus, 329 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AAK1, ADRB2, AGTR1, AKT3, ALB.