What genes are in the Negative regulation of the PI3K/AKT network pathway?

The Negative regulation of the PI3K/AKT network pathway involves 40 genes. Key genes include: AKT3, EGFR, ERBB2, ERBB3, ERBB4, ESR1, ESR2, FGF22, FGFR1, FGFR2.

Negative regulation of the PI3K/AKT network

Q: What compounds affect the Negative regulation of the PI3K/AKT network pathway?

333 compounds in the BiohacksAI corpus have documented interactions with genes in the Negative regulation of the PI3K/AKT network pathway (Reactome ID: R-HSA-199418). These compounds target 40 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-19941840 genes333 compounds

The Negative regulation of the PI3K/AKT network pathway (Reactome ID: R-HSA-199418) involves 40 genes and is affected by 333 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 EGFR ERBB2 ERBB3 ERBB4 ESR1 ESR2 FGF22 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FYN GRB2 INS INSR IRAK1 IRAK4 KIT LCK MAPK1 MAPK3 MET NTRK2 NTRK3 PDGFRA PDGFRB PIK3CB PIK3CD+10 more

Compounds Affecting Negative regulation of the PI3K/AKT network

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	sp600125	—	117
4	Crizotinib	—	298
5	Axitinib	—	298
6	Afatinib	—	297
7	tyrphostin ag 1478	—	4
8	pictilisib	—	25
9	Sirolimus	—	300
10	Quercetin	—	300
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	kenpaullone	—	8
13	ly294002	—	11
14	alsterpaullone	—	12
15	Wortmannin	—	300
16	Resveratrol	—	298
17	Kaempferols	—	300
18	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
19	alpelisib	—	227
20	Genistein	—	300
21	Dactinomycin	—	297
22	Flutamide	—	298
23	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
24	Progesterone	—	299
25	Loratadine	—	296
26	Masoprocol	—	300
27	Clotrimazole	—	296
28	pd98059	—	7
29	tyrphostin ag 1295	—	1
30	torin 1	—	10
31	Levonorgestrel	—	292
32	Norgestrel	—	300
33	Ethinyl Estradiol	—	300
34	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
35	Methyltestosterone	—	300
36	Dehydroepiandrosterone	—	300
37	Dehydroepiandrosterone	—	300
38	Fulvestrant	—	295
39	Danazol	—	298
40	Estrone	—	300
41	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
42	Rotenone	—	300
43	Dihydrotestosterone	—	300
44	Ethidium	—	300
45	Ethynodiol Diacetate	—	300
46	Estriol	—	300
47	Mestranol	—	300
48	Norethindrone	—	300
49	Oxymetholone	—	298
50	Testosterone Propionate	—	300

About the Negative regulation of the PI3K/AKT network Pathway

The Negative regulation of the PI3K/AKT network pathway is catalogued in Reactome (ID: R-HSA-199418) and involves 40 genes. In the BiohacksAI corpus, 333 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, EGFR, ERBB2, ERBB3, ERBB4.